L-LOP/LOPP for the treatment of canine gastrointestinal/ hepatosplenic lymphoma
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
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Detail(s)
| Original language | English |
|---|---|
| Article number | 1373180 |
| Journal / Publication | Frontiers in Veterinary Science |
| Volume | 11 |
| Online published | 23 May 2024 |
| Publication status | Published - 2024 |
Link(s)
| DOI | DOI |
|---|---|
| Attachment(s) | Documents
Publisher's Copyright Statement
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| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85195306608&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(225105db-bba2-4367-801a-df7c8dd7f574).html |
Abstract
Canine gastrointestinal (GI) and hepatosplenic (HS) high-grade (large cell) lymphomas are uncommon forms of canine lymphomas, with a very poor response to chemotherapy and a very poor prognosis. Currently, there are no established effective chemotherapy protocols for canine GI/HS lymphomas. This case series aimed to retrospectively evaluate the efficacy of lomustine-based protocols L-LOP (L-asparaginase, lomustine, vincristine, and prednisolone) and L-LOPP (with the addition of procarbazine) for treatment of canine GI/HS lymphomas. Medical records of dogs with cytologically or histologically diagnosed lymphoma at CityU Veterinary Medical Centre from 2019 to 2022 were retrospectively reviewed. The L-LOP/LOPP treatment protocol was well tolerated with rare severe adverse events. Median progression-free survival for GI and HS lymphoma was 56 days (range, 10–274 days) and 57 days (range 8–135 days) respectively; while median survival time for GI and HS lymphoma was 93 days (range 10–325 days) and 210 days (range 8–240 days) respectively. © 2024 Lai, Horta, Almendros, Ha and Giuliano.
Research Area(s)
- canine, lymphoma, gastrointestinal, hepatosplenic, chemotherapy, LOP, LOPP
Citation Format(s)
L-LOP/LOPP for the treatment of canine gastrointestinal/ hepatosplenic lymphoma. / Lai, Yu Ying; Horta, Rodrigo dos Santos; Almendros, Angel et al.
In: Frontiers in Veterinary Science, Vol. 11, 1373180, 2024.
In: Frontiers in Veterinary Science, Vol. 11, 1373180, 2024.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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