Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

9 Scopus Citations
View graph of relations

Author(s)

  • Jakob Trimpert
  • Julia M. Adler
  • Kathrin Eschke
  • Azza Abdelgawad
  • Theresa C. Firsching
  • Nadine Ebert
  • Tran Thi Nhu Thao
  • Achim D. Gruber
  • Volker Thiel
  • Dusan Kunec

Detail(s)

Original languageEnglish
Article numbereabk0172
Journal / PublicationScience Advances
Volume7
Issue number49
Online published1 Dec 2021
Publication statusPublished - 3 Dec 2021

Link(s)

Abstract

Vaccines are instrumental and indispensable in the fight against the COVID-19 pandemic. Several recent SARS-CoV-2 variants are more transmissible and evade infection- or vaccine-induced protection. We constructed live attenuated vaccine candidates by large-scale recoding of the SARS-CoV-2 genome and showed that the lead candidate, designated sCPD9, protects Syrian hamsters from a challenge with ancestral virus. Here, we assessed immunogenicity and protective efficacy of sCPD9 in the Roborovski dwarf hamster, a nontransgenic rodent species that is highly susceptible to SARS-CoV-2 and severe COVID-19–like disease. We show that a single intranasal vaccination with sCPD9 elicited strong cross-neutralizing antibody responses against four current SARS-CoV-2 variants of concern, B.1.1.7 (Alpha), B.1.351 (Beta), B.1.1.28.1 (Gamma), and B.1.617.2 (Delta). The sCPD9 vaccine offered complete protection from COVID-19–like disease caused by the ancestral SARS-CoV-2 variant B.1 and the two variants of concern B.1.1.7 and B.1.351.

Research Area(s)

Citation Format(s)

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta). / Trimpert, Jakob; Adler, Julia M.; Eschke, Kathrin; Abdelgawad, Azza; Firsching, Theresa C.; Ebert, Nadine; Thao, Tran Thi Nhu; Gruber, Achim D.; Thiel, Volker; Osterrieder, Nikolaus; Kunec, Dusan.

In: Science Advances, Vol. 7, No. 49, eabk0172, 03.12.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

Download Statistics

No data available