Lipid-based Vehicles for siRNA Delivery in Biomedical Field

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Detail(s)

Original languageEnglish
Pages (from-to)3-22
Journal / PublicationCurrent Pharmaceutical Biotechnology
Volume21
Issue number1
Online published24 Sep 2019
Publication statusPublished - 2020

Abstract

Background: Genetic drugs have aroused much attention in thepast twenty years. RNA interference (RNAi) offers novel insights intodiscovering potential gene functions and therapies targeting genetic diseases.Small interference RNA (siRNA), typically 21-23 nucleotides in length, canspecifically degrade complementary mRNA. However, targeted delivery andcontrolled release of siRNA remain a great challenge.

Methods: Different types of lipid-based delivery vehicleshave been synthesized, such as liposomes, lipidoids, micelles, lipoplexes andlipid nanoparticles. These carriers commonly have a core-shell structure. Foractive targeting, ligands may be conjugated to the surface of lipid particles.

Results: Lipid-based drug delivery vehicles can be utilizedin anti-viral or anti-tumor therapies. They can also be used to tackle geneticdiseases or discover novel druggable genes.

Conclusion: In this review, the structures of lipid-basedvehicles and possible surface modifications are described, and applications ofdelivery vehicles in biomedical field are discussed.

Research Area(s)

  • Delivery, Gene silencing, Lipid nanoparticle, Liposome, SiRNA, Targeting strategy