Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

89 Scopus Citations
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Author(s)

  • Zongli Zheng
  • Helena Nordenstedt
  • Nancy L. Pedersen
  • Jesper Lagergren
  • Weimin Ye

Detail(s)

Original languageEnglish
Pages (from-to)87-95
Journal / PublicationGastroenterology
Volume132
Issue number1
Publication statusPublished - Jan 2007
Externally publishedYes

Abstract

Background & Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition. Methods: In 1967 and 1973, questionnaires including lifestyle exposures were mailed to twins in the Swedish Twin Registry, and data on GER symptoms were collected by telephone interview during 1998-2002. Two analytic methods were used: external control analysis (4083 twins with GER symptoms and 21,383 controls) and monozygotic co-twin control analysis (869 monozygotic twin pairs discordant for GER symptoms). Results: In the external control analysis, leanness (body mass index [BMI]

Citation Format(s)

Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins. / Zheng, Zongli; Nordenstedt, Helena; Pedersen, Nancy L.; Lagergren, Jesper; Ye, Weimin.

In: Gastroenterology, Vol. 132, No. 1, 01.2007, p. 87-95.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review