Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 87-95 |
Journal / Publication | Gastroenterology |
Volume | 132 |
Issue number | 1 |
Publication status | Published - Jan 2007 |
Externally published | Yes |
Link(s)
Abstract
Background & Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition. Methods: In 1967 and 1973, questionnaires including lifestyle exposures were mailed to twins in the Swedish Twin Registry, and data on GER symptoms were collected by telephone interview during 1998-2002. Two analytic methods were used: external control analysis (4083 twins with GER symptoms and 21,383 controls) and monozygotic co-twin control analysis (869 monozygotic twin pairs discordant for GER symptoms). Results: In the external control analysis, leanness (body mass index [BMI]
Citation Format(s)
Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins. / Zheng, Zongli; Nordenstedt, Helena; Pedersen, Nancy L. et al.
In: Gastroenterology, Vol. 132, No. 1, 01.2007, p. 87-95.
In: Gastroenterology, Vol. 132, No. 1, 01.2007, p. 87-95.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review