Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins

Zongli Zheng; Helena Nordenstedt; Nancy L. Pedersen; Jesper Lagergren; Weimin Ye

doi:10.1053/j.gastro.2006.11.019

Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins

Zongli Zheng
, Helena Nordenstedt
, Nancy L. Pedersen
, Jesper Lagergren
, Weimin Ye

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

143 Citations (Scopus)

Abstract

Background & Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition. Methods: In 1967 and 1973, questionnaires including lifestyle exposures were mailed to twins in the Swedish Twin Registry, and data on GER symptoms were collected by telephone interview during 1998-2002. Two analytic methods were used: external control analysis (4083 twins with GER symptoms and 21,383 controls) and monozygotic co-twin control analysis (869 monozygotic twin pairs discordant for GER symptoms). Results: In the external control analysis, leanness (body mass index [BMI]

Original language	English
Pages (from-to)	87-95
Journal	Gastroenterology
Volume	132
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2006.11.019
Publication status	Published - Jan 2007
Externally published	Yes

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title = "Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins",

abstract = "Background \& Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition. Methods: In 1967 and 1973, questionnaires including lifestyle exposures were mailed to twins in the Swedish Twin Registry, and data on GER symptoms were collected by telephone interview during 1998-2002. Two analytic methods were used: external control analysis (4083 twins with GER symptoms and 21,383 controls) and monozygotic co-twin control analysis (869 monozygotic twin pairs discordant for GER symptoms). Results: In the external control analysis, leanness (body mass index [BMI]",

author = "Zongli Zheng and Helena Nordenstedt and Pedersen, \{Nancy L.\} and Jesper Lagergren and Weimin Ye",

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AU - Zheng, Zongli

AU - Nordenstedt, Helena

AU - Pedersen, Nancy L.

AU - Lagergren, Jesper

AU - Ye, Weimin

PY - 2007/1

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N2 - Background & Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition. Methods: In 1967 and 1973, questionnaires including lifestyle exposures were mailed to twins in the Swedish Twin Registry, and data on GER symptoms were collected by telephone interview during 1998-2002. Two analytic methods were used: external control analysis (4083 twins with GER symptoms and 21,383 controls) and monozygotic co-twin control analysis (869 monozygotic twin pairs discordant for GER symptoms). Results: In the external control analysis, leanness (body mass index [BMI]

AB - Background & Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) symptoms, with and without controlling for genetic predisposition. Methods: In 1967 and 1973, questionnaires including lifestyle exposures were mailed to twins in the Swedish Twin Registry, and data on GER symptoms were collected by telephone interview during 1998-2002. Two analytic methods were used: external control analysis (4083 twins with GER symptoms and 21,383 controls) and monozygotic co-twin control analysis (869 monozygotic twin pairs discordant for GER symptoms). Results: In the external control analysis, leanness (body mass index [BMI]

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DO - 10.1053/j.gastro.2006.11.019

M3 - RGC 21 - Publication in refereed journal

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SN - 0016-5085

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JO - Gastroenterology

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Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins

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