Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Qiaoling Sun
  • Hanyu Wang
  • Lingbin Shu
  • Ning Dong
  • Fan Yang
  • Hongwei Zhou
  • Rong Zhang

Detail(s)

Original languageEnglish
Article number2805
Journal / PublicationFrontiers in Microbiology
Volume10
Publication statusPublished - 5 Dec 2019
Externally publishedYes

Abstract

A clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and blaIMP-4 genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp blaIMP-4-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients. © Copyright © 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang.

Research Area(s)

  • carbapenem resistance, colistin-susceptibility, gut flora, Leclercia adecarboxylata, mcr-4.3

Citation Format(s)

Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids. / Sun, Qiaoling; Wang, Hanyu; Shu, Lingbin; Dong, Ning; Yang, Fan; Zhou, Hongwei; Chen, Sheng; Zhang, Rong.

In: Frontiers in Microbiology, Vol. 10, 2805, 05.12.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review