l-Cysteine metabolism and its nutritional implications

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Jie Yin
  • Wenkai Ren
  • Jielin Duan
  • Xingguo Huang
  • Rejun Fang
  • Chongyong Li
  • Tiejun Li
  • Yulong Yin
  • Yongqing Hou
  • Sung Woo Kim
  • Guoyao Wu

Detail(s)

Original languageEnglish
Pages (from-to)134-146
Number of pages13
Journal / PublicationMolecular Nutrition and Food Research
Volume60
Issue number1
Online published30 Apr 2015
Publication statusPublished - Jan 2016
Externally publishedYes

Abstract

L-Cysteine is a nutritionally semiessential amino acid and is present mainly in the form of L-cystine in the extracellular space. With the help of a transport system, extracellular L-cystine crosses the plasma membrane and is reduced to L-cysteine within cells by thioredoxin and reduced glutathione (GSH). Intracellular L-cysteine plays an important role in cellular homeostasis as a precursor for protein synthesis, and for production of GSH, hydrogen sulfide (H2S), and taurine. L-Cysteine-dependent synthesis of GSH has been investigated in many pathological conditions, while the pathway for L-cysteine metabolism to form H2S has received little attention with regard to prevention and treatment of disease in humans. The main objective of this review is to highlight the metabolic pathways of L-cysteine catabolism to GSH, H2S, and taurine, with special emphasis on therapeutic and nutritional use of L-cysteine to improve the health and well-being of animals and humans.

Research Area(s)

  • L-Cysteine, GSH, H2S, Nutritional potential, Taurine

Citation Format(s)

l-Cysteine metabolism and its nutritional implications. / Yin, Jie; Ren, Wenkai; Yang, Guan et al.
In: Molecular Nutrition and Food Research, Vol. 60, No. 1, 01.2016, p. 134-146.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review