TY - JOUR
T1 - LC-MS analysis of Buzhongyiqi Tang and its regulating effect on immune-depressed mice
AU - Gao, Jing-Chun
AU - Zhang, Jin-Chao
AU - Chen, Yao
AU - Bai, Gan-Rong
AU - Yang, Meng-Su
AU - Xiao, Pei-Gen
PY - 2006/8
Y1 - 2006/8
N2 - Objective: To study the main chemical constituents in Buzhongyigi Tang (BYT) and its regulating effect on immune-depressed mice treated by cyclophosphomide (CY). Methods: LC-MS Analysis of BYT, inhibitory effect of T, B lymphocyte cell proliferation and NK cell activity were observed by MTT method. Results: The main chemical constituents of BYT are polysarccharides, flavonoids, and saponins, they significantly improve the T, B lymphocyte cell proliferation and NK activity in immune-depressed mice treated by CY. Conclusion: The LC-MS method could be used in studying on active constituents in Chinese compound formula so as to elucidate their material bases of pharmacology.
AB - Objective: To study the main chemical constituents in Buzhongyigi Tang (BYT) and its regulating effect on immune-depressed mice treated by cyclophosphomide (CY). Methods: LC-MS Analysis of BYT, inhibitory effect of T, B lymphocyte cell proliferation and NK cell activity were observed by MTT method. Results: The main chemical constituents of BYT are polysarccharides, flavonoids, and saponins, they significantly improve the T, B lymphocyte cell proliferation and NK activity in immune-depressed mice treated by CY. Conclusion: The LC-MS method could be used in studying on active constituents in Chinese compound formula so as to elucidate their material bases of pharmacology.
KW - Buzhongyiqi Tang (BYT)
KW - Cyclophophomide (CY)
KW - Immunology
KW - LC-MS
UR - http://www.scopus.com/inward/record.url?scp=33749317664&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-33749317664&origin=recordpage
M3 - RGC 22 - Publication in policy or professional journal
SN - 0253-2670
VL - 37
SP - 1134
EP - 1137
JO - Chinese Traditional and Herbal Drugs
JF - Chinese Traditional and Herbal Drugs
IS - 8
ER -