Layered Double Hydroxides : A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Yixin Bian
  • Xuejie Cai
  • Zehui Lv
  • Yiming Xu
  • Han Wang
  • Ruizheng Liang
  • Xisheng Weng

Detail(s)

Original languageEnglish
Journal / PublicationAdvanced Science
Publication statusOnline published - 17 Jun 2023

Abstract

Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in the treatment of orthopedic diseases but are still plagued by deficient bioreactivity. With the development of nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition and alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, and excellent drug loading and delivery capabilities arise widespread attention and have achieved considerable achievements for bone disease treatment in the last decade. However, to the authors' best knowledge, no review has comprehensively summarized the advances of LDHs in treating bone disease so far. Herein, the advantages of LDHs for orthopedic disorders treatment are outlined and the corresponding state-of-the-art achievements are summarized for the first time. The potential of LDHs-based nanocomposites for extended therapeutics for bone diseases is highlighted and perspectives for LDHs-based scaffold design are proposed for facilitated clinical translation. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

Research Area(s)

  • 2D nanomaterial, bone disease, bone tissue engineering, layered double hydroxides, DRUG-DELIVERY SYSTEM, SYNTHETIC BIODEGRADABLE POLYMERS, MESENCHYMAL STEM-CELLS, CONTROLLED-RELEASE, IN-VITRO, GROWTH-FACTOR, ANTIBACTERIAL ACTIVITY, LUBRICANT ADDITIVES, OSTEOGENIC CELLS, PAIN MANAGEMENT

Citation Format(s)

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment. / Bian, Yixin; Cai, Xuejie; Lv, Zehui et al.
In: Advanced Science, 17.06.2023.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review