Large-scale plasmonic microarrays for label-free high-throughput screening

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

83 Scopus Citations
View graph of relations

Author(s)

  • Tsung-Yao Chang
  • Min Huang
  • Ahmet Ali Yanik
  • Hsin-Yu Tsai
  • Serap Aksu
  • Mehmet Fatih Yanik
  • Hatice Altug

Detail(s)

Original languageEnglish
Pages (from-to)3596-3602
Journal / PublicationLab on a Chip - Miniaturisation for Chemistry and Biology
Volume11
Issue number21
Publication statusPublished - 7 Nov 2011
Externally publishedYes

Abstract

Microarrays allowing simultaneous analysis of thousands of parameters can significantly accelerate screening of large libraries of pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, label-free, and high-content microarrays are needed. In this work, using large-area plasmonic nanohole arrays, we demonstrate for the first time a large-scale label-free microarray technology with over one million sensors on a single microscope slide. A dual-color filter imaging method is introduced to dramatically increase the accuracy, reliability, and signal-to-noise ratio of the sensors in a highly multiplexed manner. We used our technology to quantitatively measure protein-protein interactions. Our platform, which is highly compatible with the current microarray scanning systems can enable a powerful screening technology and facilitate diagnosis and treatment of diseases. © The Royal Society of Chemistry 2011.

Citation Format(s)

Large-scale plasmonic microarrays for label-free high-throughput screening. / Chang, Tsung-Yao; Huang, Min; Yanik, Ahmet Ali; Tsai, Hsin-Yu; Shi, Peng; Aksu, Serap; Yanik, Mehmet Fatih; Altug, Hatice.

In: Lab on a Chip - Miniaturisation for Chemistry and Biology, Vol. 11, No. 21, 07.11.2011, p. 3596-3602.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review