Landscape of extracellular vesicles in the tumour microenvironment : Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

15 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)24-44
Journal / PublicationSeminars in Cancer Biology
Volume74
Online published2 Feb 2021
Publication statusPublished - Sep 2021

Link(s)

Abstract

Extracellular vesicles (EVs) are increasingly recognised as a pivotal player in cell-cell communication, an attribute of EVs that derives from their ability to transport bioactive cargoes between cells, resulting in complex intercellular signalling mediated by EVs, which occurs under both physiological and pathological conditions. In the context of cancer, recent studies have demonstrated the versatile and crucial roles of EVs in the tumour microenvironment (TME). Here, we revisit EV biology, and focus on EV-mediated interactions between cancer cells and stromal cells, including fibroblasts, immune cells, endothelial cells and neurons. In addition, we focus on recent reports indicating interactions between EVs and non-cell constituents within the TME, including the extracellular matrix. We also review and summarise the intricate cancer-associated network modulated by EVs, which promotes metabolic reprogramming, horizontal transfer of neoplastic traits, and therapeutic resistance in the TME. We aim to provide a comprehensive and updated landscape of EVs in the TME, focusing on oncogenesis, cancer progression and therapeutic resistance, together with our future perspectives on the field.

Research Area(s)

  • Extracellular vesicles, Cancer, Tumour microenvironment, Metabolism, Metastasis, Resistance

Citation Format(s)

Landscape of extracellular vesicles in the tumour microenvironment : Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance. / Zhang, Daniel Xin; Vu, Luyen Tien; Ismail, Nur Nadiah; Le, Minh T. N.; Grimson, Andrew.

In: Seminars in Cancer Biology, Vol. 74, 09.2021, p. 24-44.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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