Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Yuetao Zhao
  • Liping Tong
  • Yong Li
  • Haobo Pan
  • Wei Zhang
  • Min Guan
  • Weihao Li
  • Yixin Chen
  • Qing Li
  • Zhongjun Li
  • Huaiyu Wang
  • Xue-Feng Yu

Detail(s)

Original languageEnglish
Pages (from-to)5813-5820
Journal / PublicationACS Applied Materials and Interfaces
Volume8
Issue number9
Publication statusPublished - 9 Mar 2016

Abstract

Timely and accurate diagnosis of cancer is crucial to cancer treatment. However, serological diagnosis of cancer still faces great challenge because the conventional methodology based on the enzyme-linked immune sorbent assay (ELISA) is costly, time-consuming, and complicated, involving multiple steps. Herein, lactose-functionalized gold nanorods (Lac-GNRs) are fabricated as efficient biosensors to detect cancerous conditions based on the unique surface plasmon resonance properties of GNRs and high specificity of lactose to the galectin-1 cancer biomarker. A trace concentration of galectin-1 as small as 10-13 M can be detected by Lac-GNRs. The comparative study among BSA, galectin-3, and galectin-1 demonstrates the good specificity of Lac-GNRs to galectin-1 either in aqueous solutions or in the complex and heterogeneous serum specimens. Clinical tests show that the Lac-GNRs biosensors can readily distinguish the serums of cancer patients from those of healthy persons simply by using a microplate reader or even direct visual observation. The Lac-GNRs biosensing platform is highly efficient and easy to use and have great potential in rapid screening of cancer patients.

Research Area(s)

  • galectin-1, gold nanorods, lactose-surface-functionalization, serological diagnosis, surface plasmon resonance

Citation Format(s)

Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. / Zhao, Yuetao; Tong, Liping; Li, Yong et al.
In: ACS Applied Materials and Interfaces, Vol. 8, No. 9, 09.03.2016, p. 5813-5820.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review