Klebsiella species : Taxonomy, hypervirulence and multidrug resistance

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Article number103998
Journal / PublicationEBioMedicine
Volume79
Online published8 Apr 2022
Publication statusPublished - May 2022

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Abstract

Members of the genus Klebsiella have rapidly evolved within the past decade, generating organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR-hv) phenotypes; such organisms are associated with severe hospital- and community-acquired infections. Carbapenem-resistant infections with unknown optimal treatment regime were of particular concern among the MDR-hv Klebsiella strains. Recent studies have revealed the molecular features and the mobile resistance elements they harbour, allowing identification of genetic loci responsible for transmission, stable inheritance, and expression of mobile resistance or virulence-encoding elements that confer the new phenotypic characteristics of MDR-hv Klebsiella spp. Here, we provide a comprehensive review on the taxonomic position, species composition and different phylotypes of Klebsiella spp., describing the diversity and worldwide distribution of the MDR-hv clones, the genetic mutation and horizontal gene transfer events that drive the evolution of such clones, and the potential impact of MDR-hv infections on human health.

Research Area(s)

  • Convergence, Evolution, Hypervirulence, Klebsiella spp., Multidrug resistance, Taxonomy

Citation Format(s)

Klebsiella species : Taxonomy, hypervirulence and multidrug resistance. / Dong, Ning; Yang, Xuemei; Chan, Edward Wai-Chi; Zhang, Rong; Chen, Sheng.

In: EBioMedicine, Vol. 79, 103998, 05.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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