Klebsiella pneumoniae infection is associated with alterations in the gut microbiome and lung metabolome
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Article number | 127139 |
Journal / Publication | Microbiological Research |
Volume | 263 |
Online published | 22 Jul 2022 |
Publication status | Published - Oct 2022 |
Link(s)
Abstract
Gut microbiota is involved in maintaining homeostasis, and intestinal dysbiosis may lead to opportunistic infections and diseases. Pathogens can disrupt the gut homeostasis and establish colonization, but how they modulate the microbiome and metabolome along the gut-lung axis warrants further investigation. In the present study, we used a classical low virulence Klebsiella pneumoniae (cKp) strain to address this question. We assessed the gut microbiome and lung metabolome in cKp-infected mice by 16S rRNA sequencing and untargeted liquid chromatography-mass spectrometry, respectively. Our data revealed that cKp infection reduced gut microbiota diversity and altered microbiome composition. Specifically, cKp infection increased the abundance of MWH-CFBk5 and Actinomadura and reduced the abundance of Lachnospiraceae_NK4A136_group, Clostridium sensu_stricto 1, Bifidobacterium, and Intestinimonas at the genus level. Notably, caffeine and caffeine metabolism were significantly affected in the lung by cKp infection. Moreover, Spearman correlation analysis revealed remarkable correlations of specific lung metabolites and bacteria species at the genus level. These findings suggest that cKp infection is linked to gut dysbiosis and alterations in the lung metabolome. This study is of significance for developing innovative gut microbiota-directed therapy for respiratory diseases.
Research Area(s)
- Dysbiosis, Gut microbiota, Klebsiella pneumoniae, Metabolome
Citation Format(s)
Klebsiella pneumoniae infection is associated with alterations in the gut microbiome and lung metabolome. / Jiang, Qianling; Xu, Qi; Kenéz, Ákos et al.
In: Microbiological Research, Vol. 263, 127139, 10.2022.
In: Microbiological Research, Vol. 263, 127139, 10.2022.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review