Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus

Ming-Liang He; Bo-jian Zheng; Ying Chen; Kin-Ling Wong; Jian-Dong Huang; Marie C. Lin; Ying Peng; Kwok Y. Yuen; Joseph J.Y. Sung; Hsiang-fu Kung

doi:10.1016/j.febslet.2006.03.066

Author(s)

Bo-jian Zheng
Ying Chen
Kin-Ling Wong
Jian-Dong Huang
Marie C. Lin
Ying Peng
Kwok Y. Yuen
Joseph J.Y. Sung
Hsiang-fu Kung

Detail(s)

Original language	English
Pages (from-to)	2414-2420
Journal / Publication	FEBS Letters
Volume	580
Issue number	10
Publication status	Published - 1 May 2006
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.febslet.2006.03.066 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-33646092274&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(2f3e4a8c-e880-46f7-b9c4-94a28d8133a8).html

Abstract

SARS-associated coronavirus was identified as the etiological agent of severe acute respiratory syndrome and a large virus pool was identified in wild animals. Virus generates drug resistance through fast mutagenesis and escapes antiviral treatment. siRNAs targeting different genes would be an alternative for overcoming drug resistance. Here, we report effective siRNAs targeting structural genes (i.e., spike, envelope, membrane, and nucleocapsid) and their antiviral kinetics. We also showed the synergistic effects of two siRNAs targeting different functional genes at a very low dose. Our findings may pave a way to develop cost effective siRNA agents for antiviral therapy in the future. © 2006.

Research Area(s)

Inhibition of SCoV reproduction, RNA interference, SARS-associated coronavirus, siRNA, Viral kinetics

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus. / He, Ming-Liang; Zheng, Bo-jian; Chen, Ying et al.
In: FEBS Letters, Vol. 580, No. 10, 01.05.2006, p. 2414-2420.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

He, M-L, Zheng, B, Chen, Y, Wong, K-L, Huang, J-D, Lin, MC, Peng, Y, Yuen, KY, Sung, JJY & Kung, H 2006, 'Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus', FEBS Letters, vol. 580, no. 10, pp. 2414-2420. https://doi.org/10.1016/j.febslet.2006.03.066

He, M.-L., Zheng, B., Chen, Y., Wong, K.-L., Huang, J.-D., Lin, M. C., Peng, Y., Yuen, K. Y., Sung, J. J. Y., & Kung, H. (2006). Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus. FEBS Letters, 580(10), 2414-2420. https://doi.org/10.1016/j.febslet.2006.03.066

He ML, Zheng B, Chen Y, Wong KL, Huang JD, Lin MC et al. Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus. FEBS Letters. 2006 May 1;580(10):2414-2420. doi: 10.1016/j.febslet.2006.03.066

He, Ming-Liang ; Zheng, Bo-jian ; Chen, Ying et al. / Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus. In: FEBS Letters. 2006 ; Vol. 580, No. 10. pp. 2414-2420.