JANUS WEDGES: A new approach towards nucleobase-pair recognition

Neil Branda; Guido Kurz; Jean-Marie Lehn

doi:10.1039/cc9960002443

JANUS WEDGES: A new approach towards nucleobase-pair recognition

Neil Branda
, Guido Kurz
, Jean-Marie Lehn

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

57 Citations (Scopus)

Abstract

The two-faced JANUS-type heterocycles 1a and 1b are designed to recognize a cytosine-uracil mismatched base-pair by insertion in a wedge-like fashion between the bases to give a triad motif utilizing the maximum number of Watson-Crick interactions, as shown by ¹H NMR spectroscopic studies.

Original language	English
Pages (from-to)	2443-2444
Journal	Chemical Communications
Issue number	21
DOIs	https://doi.org/10.1039/cc9960002443
Publication status	Published - 7 Nov 1996
Externally published	Yes

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@article{35efab9760904c648537ebde024dc8db,

title = "JANUS WEDGES: A new approach towards nucleobase-pair recognition",

abstract = "The two-faced JANUS-type heterocycles 1a and 1b are designed to recognize a cytosine-uracil mismatched base-pair by insertion in a wedge-like fashion between the bases to give a triad motif utilizing the maximum number of Watson-Crick interactions, as shown by 1H NMR spectroscopic studies.",

author = "Neil Branda and Guido Kurz and Jean-Marie Lehn",

year = "1996",

month = nov,

day = "7",

doi = "10.1039/cc9960002443",

language = "English",

pages = "2443--2444",

journal = "Chemical Communications",

issn = "0009-241X",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - JANUS WEDGES

T2 - A new approach towards nucleobase-pair recognition

AU - Branda, Neil

AU - Kurz, Guido

AU - Lehn, Jean-Marie

PY - 1996/11/7

Y1 - 1996/11/7

N2 - The two-faced JANUS-type heterocycles 1a and 1b are designed to recognize a cytosine-uracil mismatched base-pair by insertion in a wedge-like fashion between the bases to give a triad motif utilizing the maximum number of Watson-Crick interactions, as shown by 1H NMR spectroscopic studies.

AB - The two-faced JANUS-type heterocycles 1a and 1b are designed to recognize a cytosine-uracil mismatched base-pair by insertion in a wedge-like fashion between the bases to give a triad motif utilizing the maximum number of Watson-Crick interactions, as shown by 1H NMR spectroscopic studies.

UR - https://www.scopus.com/pages/publications/0040885033

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-0040885033&origin=recordpage

U2 - 10.1039/cc9960002443

DO - 10.1039/cc9960002443

M3 - RGC 21 - Publication in refereed journal

SN - 0009-241X

SP - 2443

EP - 2444

JO - Chemical Communications

JF - Chemical Communications

IS - 21

ER -

JANUS WEDGES: A new approach towards nucleobase-pair recognition

Abstract

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