Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Article number | eabn4408 |
Journal / Publication | Science Advances |
Volume | 8 |
Issue number | 30 |
Online published | 29 Jul 2022 |
Publication status | Published - 29 Jul 2022 |
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DOI | DOI |
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85135230410&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(59ed2c9f-d53b-4de5-89d9-954507c761d5).html |
Abstract
Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itch-specific neurons in the ventrolateral orbital cortex (VLO) that is distinct from the pain-related neurons. Using a Tet-Off cellular labeling system, we showed that local inhibition or activation of these itch-specific neurons in the VLO significantly suppressed or enhanced itch-induced scratching, respectively, whereas the intervention did not significantly affect pain. Conversely, suppression or activation of pain-specific neurons in the VLO significantly affected pain but not itch. Moreover, fiber photometry and immunofluorescence verified that these itch- and pain-specific neurons are distinct in their functional activity and histological location. In addition, the downstream targets of itch- and pain-specific neurons were different. Together, the present study uncovers an important subpopulation of neurons in the VLO that specifically modulates itch processing.
Research Area(s)
Citation Format(s)
Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing. / Jiang, Shan; Wang, Yi-Song; Zheng, Xiao-Xia et al.
In: Science Advances, Vol. 8, No. 30, eabn4408, 29.07.2022.
In: Science Advances, Vol. 8, No. 30, eabn4408, 29.07.2022.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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