Isomer-specific accumulation of perfluorooctanesulfonate from (N -ethyl perfluorooctanesulfonamido)ethanol-based phosphate diester in Japanese medaka (Oryzias latipes)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Hui Peng
  • Shiyi Zhang
  • Jianxian Sun
  • Zhong Zhang
  • John P. Giesy
  • And 1 others
  • Jianying Hu

Detail(s)

Original languageEnglish
Pages (from-to)1058-1066
Journal / PublicationEnvironmental Science and Technology
Volume48
Issue number2
Publication statusPublished - 21 Jan 2014

Abstract

While (N-ethyl perfluorooctanesulfonamido)ethanol (FOSE) -based phosphate diester (diSPAP) has been proposed as a candidate precursor of perfluorooctanesulfonate (PFOS), its potential biotransformation to PFOS has not been verified. Metabolism of diSPAP was investigated in Japanese medaka (Oryzias latipes) after exposure in water for 10 days, followed by 10 days of depuration. Branched isomers of diSPAP (B-diSPAP) were preferentially enriched in medaka exposed to diSPAP, with the proportion of branched isomers (BF) ranging from 0.56 to 0.80, which was significantly greater than that in the water to which the medaka were exposed (0.36) (p <0.001). This enrichment was due primarily to preferential uptake of B-diSPAP. PFOS together with perfluorooctanesulfonamide (PFOSA), N-ethyl perfluorooctanesulfonamide (NEtFOSA), 2-(perfluorooctanesulfonamido)acetic acid (FOSAA), NEtFOSAA, FOSE, and NEtFOSE were detected in medaka exposed to diSPAP, which indicated the potential for biotransformation of diSPAP to PFOS via multiple intermediates. Due to preferential metabolism of branched isomers, FOSAA and PFOSA exhibited greater BF values (>0.5) than those of NEtFOSA, NEtFOSAA, and NEtFOSE (3MPFOS, P4MPFOS, and P5MPFOS), for which values of BF were 0.58 ± 0.07, 0.62 ± 0.06, and 0.61 ± 0.05 (day 6), respectively; these values are 5.8-, 7.8-, and 6.4-fold greater than those of technical PFOS. This work provides evidence on the isomer-specific accumulation of PFOS from diSPAP and will be helpful to track indirect sources of PFOS in the future. © 2013 American Chemical Society.

Citation Format(s)

Isomer-specific accumulation of perfluorooctanesulfonate from (N -ethyl perfluorooctanesulfonamido)ethanol-based phosphate diester in Japanese medaka (Oryzias latipes). / Peng, Hui; Zhang, Shiyi; Sun, Jianxian; Zhang, Zhong; Giesy, John P.; Hu, Jianying.

In: Environmental Science and Technology, Vol. 48, No. 2, 21.01.2014, p. 1058-1066.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review