Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate-to-severe atopic dermatitis?

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
View graph of relations

Author(s)

  • Ying Liu
  • Wenkui Dai
  • Shan Wang
  • Yuan Liang
  • Chunping Shen
  • Dongfang Li
  • Yunzhu Li
  • Lei Jiao
  • Yawei Bian
  • Yi-Wei Tang
  • Lin Ma

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article numbere14215
Journal / PublicationDermatologic Therapy
Volume33
Issue number6
Online published22 Aug 2020
Publication statusPublished - Nov 2020

Abstract

The cutaneous microbiota responses to skin health as well as atopic dermatitis. To reveal the microbiota effect in atopic dermatitis children under therapy with topical corticosteroids and antibiotics. 59 atopic dermatitis patients were randomized to two treatment groups (by corticosteroids or combination therapy) in Beijing Children's Hospital. The lesion microbial samples were collected for 16S rDNA sequencing and bioinformatics analysis. After treatment, 57 patients recovered significantly. Though topical antibiotics application blocked the restoration of commensal Streptococcus, no remarkable differences of cutaneous microbiota were identified between the two groups along the treatment. In subject 1081, who received the combination therapy, the Streptococcus and Pseudomonas as well as Chryseobacterium increased dramatically. On the contrary, the Staphylococcus aureus decreased sharply in subject 1107 with topical corticosteroids treatment Our preliminary study suggested the necessity to consider cutaneous microbiota profile when prescribing antibiotics.

Research Area(s)

  • antibiotics, atopic dermatitis, cutaneous microbiota, Staphylococcus aureus, Streptococcus

Citation Format(s)

Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate-to-severe atopic dermatitis? / Liu, Ying; Zhou, Qian; Dai, Wenkui; Wang, Shan; Liang, Yuan; Li, Yinhu; Shen, Chunping; Li, Dongfang; Li, Yunzhu; Jiao, Lei; Bian, Yawei; Li, Shuaicheng; Tang, Yi-Wei; Ma, Lin.

In: Dermatologic Therapy, Vol. 33, No. 6, e14215, 11.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review