Projects per year
Abstract
In this work, an iron self-boosting polymer nanoenzyme was prepared by using pyrrole-3-carboxylic acid as a monomer and iron as an oxidizing agent via a simple and one-step method [hereafter referred to as FePPy nanoparticles (NPs)]. In fact, researchers previously paid negligible attention on the iron element during the polymerization reaction of polypyrrole, thus the intrinsically catalytic functions and enzymatic activities of the high iron content (wt %: 21.11%) are ignored and not fully explored. As expected, results demonstrate that the as-synthesized FePPy NPs can decompose H2O2 to generate hydroxyl radicals (•OH) which exhibit enzyme characteristics, further inducing a nonapoptotic ferroptosis pathway. Moreover, the nanoenzyme shows impressive photothermal properties which can accelerate the Fenton reactions to enhance ferroptosis. The combined photothermal and ferroptosis therapy of FePPy NPs was found to have high efficacy. With the properties of easy synthesis, high efficacy, and good biocompatibility, the FePPy NPs are considered as potential agents for cancer treatments.
Original language | English |
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Pages (from-to) | 30274–30283 |
Journal | ACS Applied Materials and Interfaces |
Volume | 13 |
Issue number | 26 |
Online published | 25 Jun 2021 |
DOIs | |
Publication status | Published - 7 Jul 2021 |
Research Keywords
- ferroptosis
- iron-engineered
- low-temperature photothermal therapy
- nanoenzyme
- self-boosting
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Dive into the research topics of 'Iron Self-Boosting Polymer Nanoenzyme for Low-Temperature Photothermal-Enhanced Ferrotherapy'. Together they form a unique fingerprint.Projects
- 3 Finished
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GRF: Design of Organic Charge Transfer Complex Nanoparticles for Biomedical Applications
LEE, C. S. (Principal Investigator / Project Coordinator)
1/01/21 → 17/12/24
Project: Research
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ITF: Stable Organic Nanoparticles With High Photothermal Energy Conversion Efficiencies For Biomedical And Energy Applications
LEE, C. S. (Principal Investigator / Project Coordinator)
1/12/19 → 30/11/21
Project: Research
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JLFS: Shortwave Infrared (SWIR) Imaging and Spectroscopy System for Biomedical Research
LEE, C. S. (Principal Investigator / Project Coordinator), Ge, J. (Co-Investigator), Liu, W. (Co-Investigator), SHI, P. (Co-Investigator), SUN, H. (Co-Investigator), Wang, P. F. (Co-Investigator) & ZHANG, W. (Co-Investigator)
1/07/19 → 2/06/22
Project: Research