Iron Self-Boosting Polymer Nanoenzyme for Low-Temperature Photothermal-Enhanced Ferrotherapy

Xiao Cui, Guihong Lu, Fang Fang, Yuan Xiong, Shuang Tian, Yingpeng Wan, Yafang Xiao, Dong Shen, Hui Wang, Jinfeng Zhang*, Chun-Sing Lee*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

50 Citations (Scopus)

Abstract

In this work, an iron self-boosting polymer nanoenzyme was prepared by using pyrrole-3-carboxylic acid as a monomer and iron as an oxidizing agent via a simple and one-step method [hereafter referred to as FePPy nanoparticles (NPs)]. In fact, researchers previously paid negligible attention on the iron element during the polymerization reaction of polypyrrole, thus the intrinsically catalytic functions and enzymatic activities of the high iron content (wt %: 21.11%) are ignored and not fully explored. As expected, results demonstrate that the as-synthesized FePPy NPs can decompose H2O2 to generate hydroxyl radicals (OH) which exhibit enzyme characteristics, further inducing a nonapoptotic ferroptosis pathway. Moreover, the nanoenzyme shows impressive photothermal properties which can accelerate the Fenton reactions to enhance ferroptosis. The combined photothermal and ferroptosis therapy of FePPy NPs was found to have high efficacy. With the properties of easy synthesis, high efficacy, and good biocompatibility, the FePPy NPs are considered as potential agents for cancer treatments.
Original languageEnglish
Pages (from-to)30274–30283
JournalACS Applied Materials and Interfaces
Volume13
Issue number26
Online published25 Jun 2021
DOIs
Publication statusPublished - 7 Jul 2021

Research Keywords

  • ferroptosis
  • iron-engineered
  • low-temperature photothermal therapy
  • nanoenzyme
  • self-boosting

Fingerprint

Dive into the research topics of 'Iron Self-Boosting Polymer Nanoenzyme for Low-Temperature Photothermal-Enhanced Ferrotherapy'. Together they form a unique fingerprint.

Cite this