Iridium(III) Complex–Derived Polymeric Micelles with Low Dark Toxicity and Strong NIR Excitation for Phototherapy and Chemotherapy

Jian Zhao; Xinzhong Zhang; Lei Fang; Chuanzhu Gao; Chenjie Xu; Shaohua Gou

doi:10.1002/smll.202000363

Iridium(III) Complex–Derived Polymeric Micelles with Low Dark Toxicity and Strong NIR Excitation for Phototherapy and Chemotherapy

Jian Zhao, Xinzhong Zhang, Lei Fang^*, Chuanzhu Gao, Chenjie Xu^*, Shaohua Gou^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

66 Citations (Scopus)

Abstract

Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near-infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe-based polymeric micelle system. This system is self-assembled using an iridium(III) complex-containing amphiphilic block polymer. The upconversion nanoparticles are included in the polymeric micelles to permit NIR excitation. Compared with the nonformulated iridium(III) complexes, under NIR stimulation, this polymeric micelle system exhibits higher ¹O₂ generation efficiency, negligible dark toxicity, excellent tumor-targeting ability, and synergistic phototherapy–chemotherapy effect both in vitro and in vivo.

Original language	English
Article number	2000363
Journal	Small
Volume	16
Issue number	14
Online published	16 Mar 2020
DOIs	https://doi.org/10.1002/smll.202000363
Publication status	Published - 9 Apr 2020

Funding

The authors are grateful to the National Natural Science Foundation of China (Grant Nos. 21601034 and 21571033) and Jiangsu Province Natural Science Foundation (Grant No. BK20160664) for financial aid to this work. Fundamental Research Funds for the Central Universities (Project Nos. 2242019K40142 and 2242019K40140) and Priority Academic Program Development of Jiangsu Higher Education Institutions for the construction of fundamental facilities are also appreciated. L.F. also thanks for the support of “Qing‐Lan” project in Colleges and Universities of Jiangsu Province. C.X. acknowledges the funding support from City University of Hong Kong (Grant No. #9610472). The animal procedure followed the guidelines of the Institutional Animal Care and Use Committee at KeyGEN BioTECH Co. Ltd (laboratory accreditation number: SYXK‐2017‐0015). BALB/c nude mice were purchased from Shanghai SLAC Laboratory Animal Co. Ltd.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

cancer therapy
iridium
photodynamic therapy
polymeric micelles
upconversion nanoparticles

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title = "Iridium(III) Complex–Derived Polymeric Micelles with Low Dark Toxicity and Strong NIR Excitation for Phototherapy and Chemotherapy",

abstract = "Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near-infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe-based polymeric micelle system. This system is self-assembled using an iridium(III) complex-containing amphiphilic block polymer. The upconversion nanoparticles are included in the polymeric micelles to permit NIR excitation. Compared with the nonformulated iridium(III) complexes, under NIR stimulation, this polymeric micelle system exhibits higher 1O2 generation efficiency, negligible dark toxicity, excellent tumor-targeting ability, and synergistic phototherapy–chemotherapy effect both in vitro and in vivo.",

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author = "Jian Zhao and Xinzhong Zhang and Lei Fang and Chuanzhu Gao and Chenjie Xu and Shaohua Gou",

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AU - Zhao, Jian

AU - Zhang, Xinzhong

AU - Fang, Lei

AU - Gao, Chuanzhu

AU - Xu, Chenjie

AU - Gou, Shaohua

PY - 2020/4/9

Y1 - 2020/4/9

N2 - Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near-infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe-based polymeric micelle system. This system is self-assembled using an iridium(III) complex-containing amphiphilic block polymer. The upconversion nanoparticles are included in the polymeric micelles to permit NIR excitation. Compared with the nonformulated iridium(III) complexes, under NIR stimulation, this polymeric micelle system exhibits higher 1O2 generation efficiency, negligible dark toxicity, excellent tumor-targeting ability, and synergistic phototherapy–chemotherapy effect both in vitro and in vivo.

AB - Iridium(III) complexes are potent candidates for photodynamic therapy. However, their clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible absorption in near-infrared region (NIR region). Here, it is proposed to solve these challenges by developing an iridium(III) complexe-based polymeric micelle system. This system is self-assembled using an iridium(III) complex-containing amphiphilic block polymer. The upconversion nanoparticles are included in the polymeric micelles to permit NIR excitation. Compared with the nonformulated iridium(III) complexes, under NIR stimulation, this polymeric micelle system exhibits higher 1O2 generation efficiency, negligible dark toxicity, excellent tumor-targeting ability, and synergistic phototherapy–chemotherapy effect both in vitro and in vivo.

KW - cancer therapy

KW - iridium

KW - photodynamic therapy

KW - polymeric micelles

KW - upconversion nanoparticles

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DO - 10.1002/smll.202000363

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ER -

Iridium(III) Complex–Derived Polymeric Micelles with Low Dark Toxicity and Strong NIR Excitation for Phototherapy and Chemotherapy

Abstract

Funding

UN SDGs

Research Keywords

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