Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Congcong Yin
  • Weilong Wu
  • Yang Hu
  • Cai You
  • Yuanhua Liu
  • Ziyi Chen
  • Xiu-Qin Dong
  • Xumu Zhang

Detail(s)

Original languageEnglish
Pages (from-to)2119-2124
Journal / PublicationAdvanced Synthesis and Catalysis
Volume360
Issue number11
Publication statusPublished - 5 Jun 2018
Externally publishedYes

Abstract

Iridium-catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to >99% conversion, 99% yield, >99% ee). Moreover, gram-scale experiment was performed well in the presence of just 0.005 mol% (S/C=20 000) Ir/f-amphox catalyst with 99% yield and >99% ee. (Figure presented.). © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Research Area(s)

  • Asymmetric hydrogenation, chiral halohydrins, chiral tridentate ligand, enantioselectivity, halogenated ketones

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins. / Yin, Congcong; Wu, Weilong; Hu, Yang et al.
In: Advanced Synthesis and Catalysis, Vol. 360, No. 11, 05.06.2018, p. 2119-2124.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review