Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones

Weilong Wu; Shaodong Liu; Meng Duan; Xuefeng Tan; Caiyou Chen; Yun Xie; Yu Lan; Xiu-Qin Dong; Xumu Zhang

doi:10.1021/acs.orglett.6b01290

Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones

Weilong Wu, Shaodong Liu, Meng Duan, Xuefeng Tan, Caiyou Chen, Yun Xie, Yu Lan^*, Xiu-Qin Dong, Xumu Zhang

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

132 Citations (Scopus)

Abstract

A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1"000"000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals. © 2016 American Chemical Society.

Original language	English
Pages (from-to)	2938-2941
Journal	Organic Letters
Volume	18
Issue number	12
DOIs	https://doi.org/10.1021/acs.orglett.6b01290
Publication status	Published - 17 Jun 2016
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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abstract = "A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1{"}000{"}000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals. {\textcopyright} 2016 American Chemical Society.",

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T2 - Asymmetric Hydrogenation of Simple Ketones

AU - Wu, Weilong

AU - Liu, Shaodong

AU - Duan, Meng

AU - Tan, Xuefeng

AU - Chen, Caiyou

AU - Xie, Yun

AU - Lan, Yu

AU - Dong, Xiu-Qin

AU - Zhang, Xumu

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N2 - A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1"000"000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals. © 2016 American Chemical Society.

AB - A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1"000"000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals. © 2016 American Chemical Society.

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JO - Organic Letters

JF - Organic Letters

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Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones

Abstract

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