In-vivo investigations and cytotoxicity tests on Ti/Zr-based metallic glasses with various Cu contents

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

9 Scopus Citations
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Author(s)

  • C.H. Lin
  • C.H. Chen
  • Y.S. Huang
  • C. H. Huang
  • J.S.C. Jang
  • Y.S. Lin

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)308-317
Journal / PublicationMaterials Science and Engineering C
Volume77
Online published29 Mar 2017
Publication statusPublished - 1 Aug 2017

Abstract

The Ti/Zr-based metallic glasses (MGs) with various Cu contents are prepared, with nominal compositions of Ti45Zr40Si15 (Cu-free), Ti45Zr40Si10Cu5 (low-Cu), and Ti45Zr20Cu35 (high-Cu). The mechanical properties, corrosion resistance, and in-vitro biocompatibility of these MGs are investigated by means of nano-indentation, electrochemical analyses, MTS assays and inductively coupled plasma mass spectrometry, as well as in-vivo biocompatibility in terms of scanning electron microscopy, micro-CT scans and histological observations. The results show that the electrochemical activity and biocompatibility of the MGs are sensitive to the Cu content. Following the electrocorrosion tests, an increase in ion concentration is observed in high-Cu MG. Eight independent in-vitro tests show that the higher ion concentration leads to a lower cell viability. The twelve-week in-vivo tests show that the Cu-free MGs can be a promising material for developing bio-implants. The high-Cu MG would release Ti and Zr ions with insignificant Cu ion following corrosion testing, enhancing an increased local osteoclast activity.

Research Area(s)

  • BMG, Bulk metallic glass, Copper content, Cytotoxicity, Implantation, In-vivo, Osteoconduction

Citation Format(s)

In-vivo investigations and cytotoxicity tests on Ti/Zr-based metallic glasses with various Cu contents. / Lin, C.H.; Chen, C.H.; Huang, Y.S. et al.
In: Materials Science and Engineering C, Vol. 77, 01.08.2017, p. 308-317.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review