Investigation of biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp) /graphene oxide (GO) composite for biomedical implants

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • K. Prem Ananth
  • Binbin Guo
  • Chen Zhang
  • Peng Zhou
  • Jiaming Bai

Detail(s)

Original languageEnglish
Pages (from-to)24413-24423
Journal / PublicationCeramics International
Volume46
Issue number15
Online published23 Jun 2020
Publication statusPublished - 15 Oct 2020

Abstract

The potential advantages of using 2D graphene oxide (GO)-based composites stimulating cellular differentiation as well as improve the compressive strength of the scaffolds. The present study investigated the biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp)/Graphene oxide (GO) composite with different GO (w/w) content of 1 wt%, 3 wt%, and 5 wt%. When increasing GO content, the compressive strength of scaffolds increased by 366 ± 37, 387 ± 28, and 558 ± 14 for 1 wt%, 3 wt%, and 5 wt% respectively.The TEM images showed the presence of a homogeneous distribution of BCp nanoparticles onto the graphene oxide surface; also Raman and XRD results confirm the formation of composite scaffolds. Furthermore, in vitro cytocompatibility of the BCp-PVp/GO 5 wt% composites were evaluated by cell adhesion and live/dead analysis using MG-63 cells. The obtained results showed that no adverse effect was witnessed, which evidences the superior bio compatibility nature of the composite scaffold. These results suggested that the BCp-PVp/GO composites could be a promising material for tissue engineering application.

Research Area(s)

  • Biomedical implant, Biphasic calcium phosphate, Composite, Graphene oxide, Mechanical strength

Citation Format(s)

Investigation of biphasic calcium phosphate (BCp)/polyvinylpyrrolidone (PVp) /graphene oxide (GO) composite for biomedical implants. / Prem Ananth, K.; Guo, Binbin; Zhang, Chen; Wang, Wei; Zhou, Peng; Bai, Jiaming.

In: Ceramics International, Vol. 46, No. 15, 15.10.2020, p. 24413-24423.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal