Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon-Activated Fluorescence Imaging and Photodynamic Therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Fang Fang
  • Bin Liu
  • Ji-Hua Tan
  • Yi Yuan
  • Shengliang Li
  • Qing-Xiao Tong
  • Junfang Zhao
  • Xiang-Min Meng
  • Chun-Sing Lee

Detail(s)

Original languageEnglish
Number of pages11
Journal / PublicationACS applied materials & interfaces
Online published23 Oct 2019
Publication statusOnline published - 23 Oct 2019

Abstract

A recent breakthrough in the discovery of thermally activated delayed fluorescence (TADF) emitters characterized by small single-triplet energy offsets (ΔEST) offers a wealth of new opportunities to exploit high-performance metal-free photosensitizers. In this report, two intrinsically cancer-mitochondria-targeted TADF emitters-based nanoparticles (TADF NPs) have been developed for two-photon-activated photodynamic therapy (PDT) and fluorescence imaging. The as-prepared TADF NPs integrate the merits of (1) high 1O2 quantum yield of 52%, (2) sufficient near-infrared light penetration depth due to two-photon activation, and (3) excellent structure-inherent mitochondria-targeting capabilities without extra chemical or physical modifications, inducing remarkable endogenous mitochondria-specific reactive oxygen species production and excellent cancer-cell-killing ability at an ultralow light irradiance. We believe that the development of such intrinsically multifunctional TADF NPs stemming from a single molecule will provide new insights into exploration of novel PDT agents with strong photosensitizing ability for various biomedical applications.

Research Area(s)

  • cancer-mitochondria-targeted, thermally activated delayed fluorescence (TADF), two-photon activated, fluorescence imaging, photodynamic therapy

Citation Format(s)

Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon-Activated Fluorescence Imaging and Photodynamic Therapy. / Zhang, Jinfeng; Fang, Fang; Liu, Bin; Tan, Ji-Hua; Chen, Wen-Cheng; Zhu, Zelin; Yuan, Yi; Wan, Yingpeng; Cui, Xiao; Li, Shengliang; Tong, Qing-Xiao; Zhao, Junfang; Meng, Xiang-Min; Lee, Chun-Sing.

In: ACS applied materials & interfaces, 23.10.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review