Intradermal delivery of mRNA using cryomicroneedles
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Pages (from-to) | 133-141 |
Journal / Publication | Acta Biomaterialia |
Volume | 148 |
Online published | 11 Jun 2022 |
Publication status | Published - Aug 2022 |
Link(s)
Abstract
Microneedles can realize the intradermal and transdermal delivery of drugs. However, most conventional microneedles made of metal, polymer and ceramics are unsuitable for the delivery of mRNA drugs that are fragile and temperature sensitive. This study explores the usage of cryomicroneedles (CryoMNs) for the intradermal delivery of mRNA molecules. Taking luciferase mRNA as an example, we first optimize the formulation of CryoMNs to maximize mRNA stability. Later, in the mice model, we compare the delivery efficiency with the conventional subcutaneous injection for both the luciferase mRNA and COVID-19 Comirnaty mRNA vaccines, where CryoMN delivered mRNA vaccines successfully induce specific B cell antibody, neutralizing activity and T cell responses.
Research Area(s)
- Cryomicroneedle, Intradermal delivery, mRNA, Comirnaty mRNA vaccines
Citation Format(s)
Intradermal delivery of mRNA using cryomicroneedles. / Yu, Jinming; Kuwentrai, Chaiyaporn; Gong, Hua-Rui et al.
In: Acta Biomaterialia, Vol. 148, 08.2022, p. 133-141.
In: Acta Biomaterialia, Vol. 148, 08.2022, p. 133-141.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review