Intradermal delivery of mRNA using cryomicroneedles

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

23 Scopus Citations
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Author(s)

  • Chaiyaporn Kuwentrai
  • Hua-Rui Gong
  • Renhao Li
  • Bao-zhong Zhang
  • Xuansheng Lin
  • Xiaolei Wang
  • Jian-Dong Huang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)133-141
Journal / PublicationActa Biomaterialia
Volume148
Online published11 Jun 2022
Publication statusPublished - Aug 2022

Abstract

Microneedles can realize the intradermal and transdermal delivery of drugs. However, most conventional microneedles made of metal, polymer and ceramics are unsuitable for the delivery of mRNA drugs that are fragile and temperature sensitive. This study explores the usage of cryomicroneedles (CryoMNs) for the intradermal delivery of mRNA molecules. Taking luciferase mRNA as an example, we first optimize the formulation of CryoMNs to maximize mRNA stability. Later, in the mice model, we compare the delivery efficiency with the conventional subcutaneous injection for both the luciferase mRNA and COVID-19 Comirnaty mRNA vaccines, where CryoMN delivered mRNA vaccines successfully induce specific B cell antibody, neutralizing activity and T cell responses.

Research Area(s)

  • Cryomicroneedle, Intradermal delivery, mRNA, Comirnaty mRNA vaccines

Citation Format(s)

Intradermal delivery of mRNA using cryomicroneedles. / Yu, Jinming; Kuwentrai, Chaiyaporn; Gong, Hua-Rui et al.
In: Acta Biomaterialia, Vol. 148, 08.2022, p. 133-141.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review