Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

5 Scopus Citations
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Author(s)

  • Si Si Liew
  • Chengwu Zhang
  • Lin Li
  • Shao Q. Yao

Detail(s)

Original languageEnglish
Pages (from-to)11473-11476
Journal / PublicationChemical Communications
Volume56
Issue number77
Online published19 Aug 2020
Publication statusPublished - 29 Sep 2020

Abstract

A versatile strategy for the intracellular delivery of functional proteins/antibodies was developed using N-Terminal site-specific modification. Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-Terminal site-specific modification with lysine labeling. Upon successful cytosolic uptake, the prodrug showed reactive oxygen species (ROS)-dependent targeted cancer therapy.

Citation Format(s)

Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification. / Liew, Si Si; Zhang, Chengwu; Zhang, Jie; Sun, Hongyan; Li, Lin; Yao, Shao Q.

In: Chemical Communications, Vol. 56, No. 77, 29.09.2020, p. 11473-11476.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review