Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Pages (from-to) | 11473-11476 |
Journal / Publication | Chemical Communications |
Volume | 56 |
Issue number | 77 |
Online published | 19 Aug 2020 |
Publication status | Published - 29 Sep 2020 |
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Abstract
A versatile strategy for the intracellular delivery of functional proteins/antibodies was developed using N-Terminal site-specific modification. Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-Terminal site-specific modification with lysine labeling. Upon successful cytosolic uptake, the prodrug showed reactive oxygen species (ROS)-dependent targeted cancer therapy.
Citation Format(s)
Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification. / Liew, Si Si; Zhang, Chengwu; Zhang, Jie et al.
In: Chemical Communications, Vol. 56, No. 77, 29.09.2020, p. 11473-11476.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review