Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification

Si Si Liew; Chengwu Zhang; Jie Zhang; Hongyan Sun; Lin Li; Shao Q. Yao

doi:10.1039/d0cc04728g

Author(s)

Si Si Liew
Chengwu Zhang
Lin Li
Shao Q. Yao

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	11473-11476
Journal / Publication	Chemical Communications
Volume	56
Issue number	77
Online published	19 Aug 2020
Publication status	Published - 29 Sep 2020

Link(s)

DOI	DOI https://doi.org/10.1039/d0cc04728g Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85091890875&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(5449a12b-51a6-4095-a13b-dfe6a40e5310).html

Abstract

A versatile strategy for the intracellular delivery of functional proteins/antibodies was developed using N-Terminal site-specific modification. Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed complementing N-Terminal site-specific modification with lysine labeling. Upon successful cytosolic uptake, the prodrug showed reactive oxygen species (ROS)-dependent targeted cancer therapy.

Citation Format(s)

[ RIS ] [ BibTeX ]

Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification. / Liew, Si Si; Zhang, Chengwu; Zhang, Jie ; Sun, Hongyan; Li, Lin; Yao, Shao Q.

In: Chemical Communications, Vol. 56, No. 77, 29.09.2020, p. 11473-11476.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Liew, SS, Zhang, C, Zhang, J , Sun, H, Li, L & Yao, SQ 2020, 'Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification', Chemical Communications, vol. 56, no. 77, pp. 11473-11476. https://doi.org/10.1039/d0cc04728g

Liew, S. S., Zhang, C., Zhang, J., Sun, H., Li, L., & Yao, S. Q. (2020). Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification. Chemical Communications, 56(77), 11473-11476. https://doi.org/10.1039/d0cc04728g

Liew SS, Zhang C, Zhang J , Sun H, Li L, Yao SQ. Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification. Chemical Communications. 2020 Sep 29;56(77):11473-11476. https://doi.org/10.1039/d0cc04728g

Liew, Si Si ; Zhang, Chengwu ; Zhang, Jie ; Sun, Hongyan ; Li, Lin ; Yao, Shao Q. / Intracellular delivery of therapeutic proteins through N-Terminal site-specific modification. In: Chemical Communications. 2020 ; Vol. 56, No. 77. pp. 11473-11476.