Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
|Journal / Publication||mBio|
|Online published||20 Mar 2018|
|Publication status||Published - Mar 2018|
Publisher's Copyright Statement
|Link to Scopus||https://www.scopus.com/record/display.uri?eid=2-s2.0-85046469633&origin=recordpage|
IMPORTANCE West Nile virus is an emerging mosquito-borne flavivirus that can result in serious illness, neuropathology, and death in infected individuals. Currently, there are no vaccines or therapies for human use against West Nile virus. Immune control of West Nile virus infection requires inflammatory and antiviral responses, though the effect that each arm of this response has on the other is unclear. The significance of our research is in defining how virus-induced inflammatory responses regulate critical antiviral immune programs for effective control of West Nile virus infection. These data identify essential mechanisms of immune control that can inform therapeutic efforts against West Nile virus, with potential efficacy against other neuroinvasive viruses.
- Flavivirus, Genomics, IL-1, Inflammasome, Innate immunity, Interferon, Virus, West nile virus
Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses. / Aarreberg, Lauren D.; Wilkins, Courtney; Ramos, Hilario J.; Green, Richard; Davis, Michael A.; Chow, Kwan; Gale, Jr., Michael.In: mBio, Vol. 9, No. 2, e00342-18, 03.2018.