TY - JOUR
T1 - Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection
AU - Li, Josephine H.
AU - Lao, Xiang Qian
AU - Tillmann, Hans L.
AU - Rowell, Jennifer
AU - Patel, Keyur
AU - Thompson, Alexander
AU - Suchindran, Sunil
AU - Muir, Andrew J.
AU - Guyton, John R.
AU - Gardner, Stephen D.
AU - McHutchison, John G.
AU - McCarthy, Jeanette J.
PY - 2010/6
Y1 - 2010/6
N2 - Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN. We sought to determine if the IFN-lambda gene variant was also associated with serum lipid levels in chronic hepatitis C patients. We compared genotypes of the rs12979860 polymorphism, located proximal to the IL28 gene, with serum lipid and apolipoprotein levels in 746 subjects with chronic hepatitis C virus infection, not currently undergoing treatment, using multivariable analysis of variance. Levels of total cholesterol (P = 6.0 × 10-4), apolipoprotein B (P = 1.3 × 10-6) and low-density lipoprotein (LDL) cholesterol (P = 8.9 × 10-10) were significantly higher in subjects carrying the rs12979860 CC responder genotype compared with those with the CTor TT genotype. Levels of triglycerides (P = 0.03), apolipoprotein A-I (P = 0.06), and apolipoprotein E (P = 0.01) were slightly lower in the rs12979860 CC genotype group, whereas levels of high-density lipoprotein cholesterol (P = 0.78) and apolipoprotein C-III (P = 0.74) did not vary by rs12979860 genotype. Conclusion: Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus.
AB - Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN. We sought to determine if the IFN-lambda gene variant was also associated with serum lipid levels in chronic hepatitis C patients. We compared genotypes of the rs12979860 polymorphism, located proximal to the IL28 gene, with serum lipid and apolipoprotein levels in 746 subjects with chronic hepatitis C virus infection, not currently undergoing treatment, using multivariable analysis of variance. Levels of total cholesterol (P = 6.0 × 10-4), apolipoprotein B (P = 1.3 × 10-6) and low-density lipoprotein (LDL) cholesterol (P = 8.9 × 10-10) were significantly higher in subjects carrying the rs12979860 CC responder genotype compared with those with the CTor TT genotype. Levels of triglycerides (P = 0.03), apolipoprotein A-I (P = 0.06), and apolipoprotein E (P = 0.01) were slightly lower in the rs12979860 CC genotype group, whereas levels of high-density lipoprotein cholesterol (P = 0.78) and apolipoprotein C-III (P = 0.74) did not vary by rs12979860 genotype. Conclusion: Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus.
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U2 - 10.1002/hep.23592
DO - 10.1002/hep.23592
M3 - RGC 21 - Publication in refereed journal
C2 - 20235331
AN - SCOPUS:77952730427
SN - 0270-9139
VL - 51
SP - 1904
EP - 1911
JO - Hepatology
JF - Hepatology
IS - 6
ER -
