Abstract
Spatial and temporal precisely control of direction and speed is crucial for nanomotors to enable complex operations and applications in microsurgery, drug delivery, isolation of biological targets, and so on. Judicious material design involving Janus nanoparticles has been popular over the past decades, however, precise and customizable modulation of Janus structure with a specific asymmetric ratio for motion control is still challenging. In this study, a universal “interface allocation” strategy is developed for efficient and controllable preparation of Janus mesoporous silica-coated upconversion nanoparticles (Janus UCNP@mSiO2) with precisely tuned asymmetric ratio to achieve near-infrared (NIR)-controlled active mobility for relieving vessel plaque. Mesoporous silica with a thickness of 50 nm is precisely coated onto the nanoparticles’ surface with an optimal coverage ratio of 50% to encapsulate gas propellant. Upon exposure to upconverted blue light, the nanomotors release nitric oxide, facilitating their motion and pathologically improving atherosclerosis through endothelium-dependent vasodilation. Experimental and theoretical simulation results demonstrate the advantages of NIR-controlled Janus upconversion nanomotors in atherosclerosis treatment, including enhanced nanoparticle-transmittance rate (34.83% to 85.57%) and excellent in vivo therapeutic efficacy. © 2024 Wiley-VCH GmbH.
| Original language | English |
|---|---|
| Article number | 2405916 |
| Journal | Advanced Functional Materials |
| Volume | 34 |
| Issue number | 41 |
| Online published | 2 Jul 2024 |
| DOIs | |
| Publication status | Published - 8 Oct 2024 |
Research Keywords
- enhanced bioavailability
- heterostructures
- morphology tuning
- nitric oxide
- vessel plaque
Publisher's Copyright Statement
- COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the accepted version of the following article: Zhang, Y., Liao, C., Abudusaimaiti, M., Zhou, H., Liu, J., Li, W., Zhang, Y., & Mei, Q. (2024). Interface Allocation Precisely Customized Janus Upconversion Nanomotor for Atherosclerosis Amelioration. Advanced Functional Materials, 34(41), Article 2405916
- which has been published in final form at https://doi.org/10.1002/adfm.202405916. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.