Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yi Wan
  • Fengyan Liu
  • Steve Wiseman
  • Xiaowei Zhang
  • Hong Chang
  • Markus Hecker
  • Paul D. Jones
  • John P. Giesy

Detail(s)

Original languageEnglish
Pages (from-to)8729-8735
Journal / PublicationEnvironmental Science and Technology
Volume44
Issue number22
Publication statusPublished - 15 Nov 2010

Abstract

Polybrominated diphenyl ethers (PBDEs), hydroxylated (OH) and methoxylated (MeO), have been widely detected in aquatic environments. However, relationships among these structurally related compounds in exposed organisms are unclear. To elucidate biotransformation relationships among BDE-47, 6-OH-BDE-47, and 6-MeO-BDE-47, dietary accumulation, maternal transfer, and tissue distribution of these compounds and their transformation products were investigated in sexually mature Japanese medaka (Oryzias latipes). In addition, transformation of each compound was determined in vitro using liver microsomes of medaka. OH-PBDEs and MeO-PBDEs were not detected in fish exposed to BDE-47. However, significant concentrations of 6-OH-BDE-47 were detected in medaka or microsomes exposed to 6-MeO-BDE-47. Significant concentrations of 6-MeO-BDE-47 were also measured in fish exposed to 6-OH-BDE-47, but 6-MeO-BDE-47 was not detected in microsomes exposed to 6-OH-BDE-47. Similar patterns of transformation products were observed in medaka eggs from adult fish during exposure. This study presents direct in vivo evidence of biotransformation of 6-MeO-BDE-47 to 6-OH-BDE-47. In addition, this is the first study to demonstrate biotransformation of 6-OH-BDE-47 to 6-MeO-BDE-47. Demethylation of 6-MeO-BDE-47 was the primary transformation pathway leading to formation of 6-OH-BDE-47 in medaka, while the previously hypothesized formation of OH-PBDEs from synthetic BDE-47 did not occur. Biotransformation products formed in adult female medaka were transferred to eggs. © 2010 American Chemical Society.

Citation Format(s)

Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka. / Wan, Yi; Liu, Fengyan; Wiseman, Steve; Zhang, Xiaowei; Chang, Hong; Hecker, Markus; Jones, Paul D.; Lam, Michael H. W.; Giesy, John P.

In: Environmental Science and Technology, Vol. 44, No. 22, 15.11.2010, p. 8729-8735.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review