TY - CHAP
T1 - Interaction of dietary calcium with genes of transporters, receptors and enzymes involved in cholesterol metabolism
AU - Wang, Xiaobo
AU - Lei, Lin
AU - Liu, Yuwei
AU - Ma, Ka Ying
AU - Chen, Jingnan
AU - Jiao, Rui
AU - Huang, Yu
AU - Chen, Zhen-Yu
N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
PY - 2016
Y1 - 2016
N2 - Dietary calcium has been shown to decrease plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol, particularly in postmenopausal women who have regularly taken calcium supplement for prevention of osteoporosis. Two possible mechanisms are associated with cholesterol-lowering activity of calcium supplement. First, calcium increases the bile-acid excretion due to its binding interaction with bile acids in the intestine. This is companied by upregulation of cholesterol-7α-hydroxylase (CYP7A1), a key enzyme in converting cholesterol to bile acids in the liver. Secondly, calcium supplement increases the cholesterol excretion, possibly mediated by downregulation of intestinal Niemann-Pick C1 like 1 (NPC1L1) and acyl coenzyme A: cholesterol acyltransferase 2 (ACAT-2), both of which are responsible for cholesterol absorption.
AB - Dietary calcium has been shown to decrease plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol, particularly in postmenopausal women who have regularly taken calcium supplement for prevention of osteoporosis. Two possible mechanisms are associated with cholesterol-lowering activity of calcium supplement. First, calcium increases the bile-acid excretion due to its binding interaction with bile acids in the intestine. This is companied by upregulation of cholesterol-7α-hydroxylase (CYP7A1), a key enzyme in converting cholesterol to bile acids in the liver. Secondly, calcium supplement increases the cholesterol excretion, possibly mediated by downregulation of intestinal Niemann-Pick C1 like 1 (NPC1L1) and acyl coenzyme A: cholesterol acyltransferase 2 (ACAT-2), both of which are responsible for cholesterol absorption.
UR - https://www.scopus.com/pages/publications/84952910758
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84952910758&origin=recordpage
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000387994300032
U2 - 10.1039/9781782622130-00519
DO - 10.1039/9781782622130-00519
M3 - RGC 12 - Chapter in an edited book (Author)
VL - 2016-January
T3 - Food and Nutritional Components in Focus
SP - 519
EP - 529
BT - Calcium: Chemistry, Analysis, Function and Effects
PB - Royal Society of Chemistry
ER -