Interaction between the fluorinated amphiphilic copolymer poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-graft-poly(SPEG) and DNA

Ling Li; Shengdong Xiong; Yingxi Wang; Gongwu Song; Shuilin Wu; Paul K. Chu; Zushun Xu

doi:10.1002/app.32339

Author(s)

Ling Li
Shengdong Xiong
Yingxi Wang
Gongwu Song
Shuilin Wu
Zushun Xu

Detail(s)

Original language	English
Pages (from-to)	291-298
Journal / Publication	Journal of Applied Polymer Science
Volume	118
Issue number	1
Publication status	Published - 5 Oct 2010

Link(s)

DOI	DOI https://doi.org/10.1002/app.32339 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-77955957562&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(20e9628b-3f32-4999-924a-5c8ea74a0647).html

Abstract

A synthesized copolymer, synthesized from HFMA (hexaflurobutyl methacrylate) and SPEG (PHFMA-_g-PSPEG), was synthesized. PHFMA- _g-PSPEG intercalated to the DNA base pair via a strong hydrophobic force, and this was conformed by ultraviolet spectroscopy, transmittance measurements, micropolarity measurements, resonance light scattering (RLS) spectroscopy, and particle size measurements. The copolymer was used as a new probe to detect DNA according to the RLS technique. The hydrophobic interaction between PHFMA-_g-PSPEG and DNA significantly enhanced the RLS signal, and the enhanced RLS intensity at 422 nm was proportional to the nucleic acid concentration within the range of 0.09-0.90 mg/L with a detection limit (3σ) of 4.0 μg/L. © 2010 Wiley Periodicals, Inc.

Research Area(s)

Biological applications of polymers, Drug delivery systems, Fluoropolymers

Citation Format(s)

[ RIS ] [ BibTeX ]

Interaction between the fluorinated amphiphilic copolymer poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-graft-poly(SPEG) and DNA. / Li, Ling; Xiong, Shengdong; Wang, Yingxi et al.
In: Journal of Applied Polymer Science, Vol. 118, No. 1, 05.10.2010, p. 291-298.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Li, L, Xiong, S, Wang, Y, Song, G, Wu, S, Chu, PK & Xu, Z 2010, 'Interaction between the fluorinated amphiphilic copolymer poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-graft-poly(SPEG) and DNA', Journal of Applied Polymer Science, vol. 118, no. 1, pp. 291-298. https://doi.org/10.1002/app.32339

Li, L., Xiong, S., Wang, Y., Song, G., Wu, S., Chu, P. K., & Xu, Z. (2010). Interaction between the fluorinated amphiphilic copolymer poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-graft-poly(SPEG) and DNA. Journal of Applied Polymer Science, 118(1), 291-298. https://doi.org/10.1002/app.32339

Li L, Xiong S, Wang Y, Song G, Wu S, Chu PK et al. Interaction between the fluorinated amphiphilic copolymer poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-graft-poly(SPEG) and DNA. Journal of Applied Polymer Science. 2010 Oct 5;118(1):291-298. doi: 10.1002/app.32339

Li, Ling ; Xiong, Shengdong ; Wang, Yingxi et al. / Interaction between the fluorinated amphiphilic copolymer poly(2,2,3,4,4,4-hexafluorobutyl methacrylate)-graft-poly(SPEG) and DNA. In: Journal of Applied Polymer Science. 2010 ; Vol. 118, No. 1. pp. 291-298.