Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning

Xingcan Huang; Yiming Liu; Wooyoung Park; Jiyu Li; Jie Ma; Chun Ki Yiu; Qiang Zhang; Jian Li; Pengcheng Wu; Jingkun Zhou; Yuyang Zeng; Xinxin He; Jialin Li; Tsz Hung Wong; Kuanming Yao; Ling Zhao; Yuyu Gao; Rui Shi; Hu Li; Meixi Li; Dengfeng Li; Zhao Zhao; Yuhang Li; Heng Li; Xinge Yu

doi:10.1002/adhm.202202846

Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning

Xingcan Huang, Yiming Liu, Wooyoung Park, Jiyu Li, Jie Ma, Chun Ki Yiu, Qiang Zhang, Jian Li, Pengcheng Wu, Jingkun Zhou, Yuyang Zeng, Xinxin He, Jialin Li, Tsz Hung Wong, Kuanming Yao, Ling Zhao, Yuyu Gao, Rui Shi, Hu Li, Meixi LiDengfeng Li, Zhao Zhao^*, Yuhang Li^*, Heng Li^*, Xinge Yu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

31 Citations (Scopus)

Abstract

Intelligent monitoring human physiological information in real time raises the demand for skin-integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring. The biofluid such as sweat from skin contains abundant biomarkers reflecting body health conditions. Here, a skin-integrated sweat monitor with six biosensors embedded for the detection of NH₄⁺, Na⁺, glucose, pH, skin impedance, and surface temperature is described, which could decode the information in the fresh sweat generated during exercising. Furthermore, the system also includes an innovative safety warning mechanism, which is based on a miniaturized actuator to provide mechanical stimuli, and coupled with six changeable colors light emitting diodes corresponding to the six biosensors for providing simultaneous safety alarming to users. The self-developed microfluidics system with a hydrophilic surface allows to enhance the sweat collection rate. Meanwhile, microfluidic filters can reduce the interruption of skin debris during biosignal monitoring. These state-of-art biosensors can real-time monitor health related signals with excellent linearity and specificity. The skin-integrated sweat monitor system exhibits a great potential in human healthcare monitoring and medical treatment. © 2023 Wiley-VCH GmbH.

Original language	English
Article number	2202846
Journal	Advanced Healthcare Materials
Volume	12
Issue number	15
Online published	11 Feb 2023
DOIs	https://doi.org/10.1002/adhm.202202846
Publication status	Published - 13 Jun 2023

Funding

X.H., Y.L., W.P., and J.L. contributed equally to this work. All experiments involving human subjects were approved by City University of Hong Kong, and conducted in compliance with the guidelines. All participants for the studies were fully voluntary and submitted their informed consent. This work was supported by City University of Hong Kong (Grants Nos. 9667221 and 9680322), Research Grants Council of the Hong Kong Special Administrative Region (Grant Nos. 21210820 and 11213721), National Natural Science Foundation of China (Grant No. 62122002), Innovation and Technology Fund of Innovation and Technology Commission (GHP/095/20GD), Shenzhen Science and Technology Innovation Commission (Grant No. JCYJ20200109110201713), and General Research Fund of Hong Kong Special Administrative Region (Grant Nos. 15210720 and 15201621). This work was also sponsored by InnoHK Project on Project 2.2—artificial intelligent (AI)-based 3D ultrasound imaging algorithm at Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Center of Flexible Electronics Technology, and Qiantang Science and Technology Innovation Center.

Research Keywords

cloosed-loop
microfluidics
safety alarming
skin-integrated electronics
sweat biosensors

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Huang, X., Liu, Y., Park, W., Li, J., Ma, J., Yiu, C. K., Zhang, Q., Li, J., Wu, P., Zhou, J., Zeng, Y., He, X., Li, J., Wong, T. H., Yao, K., Zhao, L., Gao, Y., Shi, R., Li, H., ... Yu, X. (2023). Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning. Advanced Healthcare Materials, 12(15), Article 2202846. https://doi.org/10.1002/adhm.202202846

@article{8b1347b680314e27bbc455863d5e9e55,

title = "Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning",

abstract = "Intelligent monitoring human physiological information in real time raises the demand for skin-integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring. The biofluid such as sweat from skin contains abundant biomarkers reflecting body health conditions. Here, a skin-integrated sweat monitor with six biosensors embedded for the detection of NH4+, Na+, glucose, pH, skin impedance, and surface temperature is described, which could decode the information in the fresh sweat generated during exercising. Furthermore, the system also includes an innovative safety warning mechanism, which is based on a miniaturized actuator to provide mechanical stimuli, and coupled with six changeable colors light emitting diodes corresponding to the six biosensors for providing simultaneous safety alarming to users. The self-developed microfluidics system with a hydrophilic surface allows to enhance the sweat collection rate. Meanwhile, microfluidic filters can reduce the interruption of skin debris during biosignal monitoring. These state-of-art biosensors can real-time monitor health related signals with excellent linearity and specificity. The skin-integrated sweat monitor system exhibits a great potential in human healthcare monitoring and medical treatment. {\textcopyright} 2023 Wiley-VCH GmbH.",

keywords = "cloosed-loop, microfluidics, safety alarming, skin-integrated electronics, sweat biosensors",

author = "Xingcan Huang and Yiming Liu and Wooyoung Park and Jiyu Li and Jie Ma and Yiu, {Chun Ki} and Qiang Zhang and Jian Li and Pengcheng Wu and Jingkun Zhou and Yuyang Zeng and Xinxin He and Jialin Li and Wong, {Tsz Hung} and Kuanming Yao and Ling Zhao and Yuyu Gao and Rui Shi and Hu Li and Meixi Li and Dengfeng Li and Zhao Zhao and Yuhang Li and Heng Li and Xinge Yu",

year = "2023",

month = jun,

day = "13",

doi = "10.1002/adhm.202202846",

language = "English",

volume = "12",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "John Wiley & Sons",

number = "15",

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Huang, X , Liu, Y , Park, W , Li, J, Ma, J, Yiu, CK, Zhang, Q, Li, J , Wu, P , Zhou, J, Zeng, Y, He, X, Li, J, Wong, TH , Yao, K , Zhao, L , Gao, Y, Shi, R, Li, H, Li, M, Li, D, Zhao, Z, Li, Y, Li, H & Yu, X 2023, 'Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning', Advanced Healthcare Materials, vol. 12, no. 15, 2202846. https://doi.org/10.1002/adhm.202202846

TY - JOUR

T1 - Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning

AU - Huang, Xingcan

AU - Liu, Yiming

AU - Park, Wooyoung

AU - Li, Jiyu

AU - Ma, Jie

AU - Yiu, Chun Ki

AU - Zhang, Qiang

AU - Li, Jian

AU - Wu, Pengcheng

AU - Zhou, Jingkun

AU - Zeng, Yuyang

AU - He, Xinxin

AU - Li, Jialin

AU - Wong, Tsz Hung

AU - Yao, Kuanming

AU - Zhao, Ling

AU - Gao, Yuyu

AU - Shi, Rui

AU - Li, Hu

AU - Li, Meixi

AU - Li, Dengfeng

AU - Zhao, Zhao

AU - Li, Yuhang

AU - Li, Heng

AU - Yu, Xinge

PY - 2023/6/13

Y1 - 2023/6/13

N2 - Intelligent monitoring human physiological information in real time raises the demand for skin-integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring. The biofluid such as sweat from skin contains abundant biomarkers reflecting body health conditions. Here, a skin-integrated sweat monitor with six biosensors embedded for the detection of NH4+, Na+, glucose, pH, skin impedance, and surface temperature is described, which could decode the information in the fresh sweat generated during exercising. Furthermore, the system also includes an innovative safety warning mechanism, which is based on a miniaturized actuator to provide mechanical stimuli, and coupled with six changeable colors light emitting diodes corresponding to the six biosensors for providing simultaneous safety alarming to users. The self-developed microfluidics system with a hydrophilic surface allows to enhance the sweat collection rate. Meanwhile, microfluidic filters can reduce the interruption of skin debris during biosignal monitoring. These state-of-art biosensors can real-time monitor health related signals with excellent linearity and specificity. The skin-integrated sweat monitor system exhibits a great potential in human healthcare monitoring and medical treatment. © 2023 Wiley-VCH GmbH.

AB - Intelligent monitoring human physiological information in real time raises the demand for skin-integrated electronics, as which is a flexible format and can be mounted onto the curved human skin for noninvasive healthcare monitoring. The biofluid such as sweat from skin contains abundant biomarkers reflecting body health conditions. Here, a skin-integrated sweat monitor with six biosensors embedded for the detection of NH4+, Na+, glucose, pH, skin impedance, and surface temperature is described, which could decode the information in the fresh sweat generated during exercising. Furthermore, the system also includes an innovative safety warning mechanism, which is based on a miniaturized actuator to provide mechanical stimuli, and coupled with six changeable colors light emitting diodes corresponding to the six biosensors for providing simultaneous safety alarming to users. The self-developed microfluidics system with a hydrophilic surface allows to enhance the sweat collection rate. Meanwhile, microfluidic filters can reduce the interruption of skin debris during biosignal monitoring. These state-of-art biosensors can real-time monitor health related signals with excellent linearity and specificity. The skin-integrated sweat monitor system exhibits a great potential in human healthcare monitoring and medical treatment. © 2023 Wiley-VCH GmbH.

KW - cloosed-loop

KW - microfluidics

KW - safety alarming

KW - skin-integrated electronics

KW - sweat biosensors

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85149037478&origin=recordpage

U2 - 10.1002/adhm.202202846

DO - 10.1002/adhm.202202846

M3 - RGC 21 - Publication in refereed journal

C2 - 36773301

SN - 2192-2640

VL - 12

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 15

M1 - 2202846

ER -

Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning

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GRF: Intelligent Electronic Skin for Human Machine Interactions

ITF: Electronic Skin and Haptic Interfaces for Intelligent Prosthesis

ECS: Skin-Integrated Sensing and Haptic Feedback Electronics for Health Monitoring and Sudden Illnesses Early Warning

Cite this

Intelligent Soft Sweat Sensors for the Simultaneous Healthcare Monitoring and Safety Warning

Abstract

Funding

Research Keywords

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Projects

GRF: Intelligent Electronic Skin for Human Machine Interactions

ITF: Electronic Skin and Haptic Interfaces for Intelligent Prosthesis

ECS: Skin-Integrated Sensing and Haptic Feedback Electronics for Health Monitoring and Sudden Illnesses Early Warning

Cite this