Intelligent Phase Contrast Meta-Microscope System

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

1 Scopus Citations
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Author(s)

  • Cheng Hung Chu
  • Yu-Hsin Chia
  • Hung-Chuan Hsu
  • Sunil Vyas
  • Chen-Ming Tsai
  • Takeshi Yamaguchi
  • Takuo Tanaka
  • Huei-Wen Chen
  • Yuan Luo
  • Pan-Chyr Yang

Detail(s)

Original languageEnglish
Pages (from-to)11630−11637
Journal / PublicationNano Letters
Volume23
Issue number24
Online published1 Dec 2023
Publication statusPublished - 27 Dec 2023

Abstract

Phase contrast imaging techniques enable the visualization of disparities in the refractive index among various materials. However, these techniques usually come with a cost: the need for bulky, inflexible, and complicated configurations. Here, wepropose and experimentally demonstrate an ultracompact meta-microscope, a novel imaging platform designed to accomplish both optical and digital phase contrast imaging. The optical phase contrast imaging system is composed of a pair of metalenses and an intermediate spiral phase metasurface located at the Fourier plane.The performance of the system in generating edge-enhance dimages is validated by imaging a variety of human cells, including lung cell lines BEAS-2B, CLY1, and H1299 and other types.Additionally, we integrate the ResNet deep learning model into the meta-microscope to transform bright-field images into edge-enhanced images with high contrast accuracy. This technology promises to aid in the development of innovative miniature optical systems for biomedical and clinical applications.

© 2023 American Chemical Society

Citation Format(s)

Intelligent Phase Contrast Meta-Microscope System. / Chu, Cheng Hung; Chia, Yu-Hsin; Hsu, Hung-Chuan et al.
In: Nano Letters, Vol. 23, No. 24, 27.12.2023, p. 11630−11637.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review