Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans : Gut Microbes

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

12 Scopus Citations
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Author(s)

  • Liwei Chen
  • Tingting Zheng
  • Yifan Yang
  • Prem Prashant Chaudhary
  • Jean Pui Yi Teh
  • Bobby K. Cheon
  • Daniela Moses
  • Stephan C. Schuster
  • Joergen Schlundt
  • Patricia L. Conway

Detail(s)

Original languageEnglish
Article number2070392
Journal / PublicationGut Microbes
Volume14
Issue number1
Online published12 May 2022
Publication statusPublished - 2022

Link(s)

Abstract

The age-associated alterations in microbiomes vary across populations due to the influence of genetics and lifestyles. To the best of our knowledge, the microbial changes associated with aging have not yet been investigated in Singapore adults. We conducted shotgun metagenomic sequencing of fecal and saliva samples, as well as fecal metabolomics to characterize the gut and oral microbial communities of 62 healthy adult male Singaporeans, including 32 young subjects (age, 23.1 ± 1.4 years) and 30 elderly subjects (age, 69.0 ± 3.5 years). We identified 8 gut and 13 oral species that were differentially abundant in elderly compared to young subjects. By combining the gut and oral microbiomes, 25 age-associated oral-gut species connections were identified. Moreover, oral bacteria Acidaminococcus intestine and Flavonifractor plautii were less prevalent/abundant in elderly gut samples than in young gut samples, whereas Collinsella aerofaciens and Roseburia hominis showed the opposite trends. These results indicate the varied gut-oral communications with aging. Subsequently, we expanded the association studies on microbiome, metabolome and host phenotypic parameters. In particular, Eubacterium eligens increased in elderly compared to young subjects, and was positively correlated with triglycerides, which implies that the potential role of E. eligens in lipid metabolism is altered during the aging process. Our results demonstrated aging-associated changes in the gut and oral microbiomes, as well as the connections between metabolites and host-microbe interactions, thereby deepening the understanding of alterations in the human microbiome during the aging process in a Singapore population.

Research Area(s)

  • Microbiome, fecal metabolome, multi-omics, integrative analysis, aging

Citation Format(s)

Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans: Gut Microbes. / Chen, Liwei; Zheng, Tingting; Yang, Yifan et al.
In: Gut Microbes, Vol. 14, No. 1, 2070392, 2022.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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