TY - CHAP
T1 - Integrative and reductionist approaches to modeling of control of breathing
AU - Tin, C.
AU - Poon, C. S.
PY - 2012/12/14
Y1 - 2012/12/14
N2 - Integration and reductionism represent two different modeling approaches in understanding the working mechanism of a system. Traditionally, biological modeling has relied on reductionism, which has the advantage of decomposing the intrinsic complexity of biological systems into smaller subsystems to ease understanding. However, as more information accumulates, it becomes increasingly difficult to integrate these components systematically to explain more complex behavior, particularly when multiple determining factors co-exist. In this chapter, we compare the reductionist and integrative views of biological modeling. The value of integrative modeling is discussed from the perspective of engineering and physics point of view. The need for an integrative approach is illustrated in the context of respiratory control. © Springer-Verlag Berlin Heidelberg 2013.
AB - Integration and reductionism represent two different modeling approaches in understanding the working mechanism of a system. Traditionally, biological modeling has relied on reductionism, which has the advantage of decomposing the intrinsic complexity of biological systems into smaller subsystems to ease understanding. However, as more information accumulates, it becomes increasingly difficult to integrate these components systematically to explain more complex behavior, particularly when multiple determining factors co-exist. In this chapter, we compare the reductionist and integrative views of biological modeling. The value of integrative modeling is discussed from the perspective of engineering and physics point of view. The need for an integrative approach is illustrated in the context of respiratory control. © Springer-Verlag Berlin Heidelberg 2013.
UR - https://www.scopus.com/pages/publications/84893098630
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84893098630&origin=recordpage
U2 - 10.1007/978-3-642-32882-4_5
DO - 10.1007/978-3-642-32882-4_5
M3 - RGC 12 - Chapter in an edited book (Author)
SN - 9783642328817
T3 - Lecture Notes in Mathematics
SP - 89
EP - 103
BT - Mathematical Modeling and Validation in Physiology
A2 - Batzel, Jerry J
A2 - Bachar, Mostafa
A2 - Kappel, Franz
PB - Springer Berlin Heidelberg
CY - Berlin, Heidelberg
ER -