INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS

Anirban Sinha; Tse-Yu Tai; Yu-Lin Wang; Gwo-Bin Lee

doi:10.1109/MEMSYS.2018.8346541

INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS

Anirban Sinha, Tse-Yu Tai, Yu-Lin Wang^*, Gwo-Bin Lee

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

5 Citations (Scopus)

Abstract

This study presents an integrated microfluidic platform equipped with a field-effect-transistor sensor array which is capable of performing analysis beyond Debye length and detecting protein biomarkers associated with cardiovascular diseases from clinical samples within a short period of time. This work also demonstrates a prototype for future point-of-care device on which antibodies could be replaced by highly specific aptamers. In order to demonstrate the capability of the developed device, four cardiovascular biomarkers (CRP, NT-proBNP, troponin I, fibrinogen) were chosen and their physiological as well as risk concentrations were analyzed simultaneously in a single chip.

Original language	English
Title of host publication	2018 IEEE Micro Electro Mechanical Systems (MEMS)
Publisher	IEEE
Pages	286-289
ISBN (Electronic)	9781538647820
DOIs	https://doi.org/10.1109/MEMSYS.2018.8346541
Publication status	Published - Jan 2018
Externally published	Yes
Event	31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018) - Belfast, United Kingdom Duration: 21 Jan 2018 → 25 Jan 2018 https://www.mems2018.org/

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Publisher	IEEE
ISSN (Print)	1084-6999
ISSN (Electronic)	2160-1968

Conference

Conference	31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018)
Country/Territory	United Kingdom
City	Belfast
Period	21/01/18 → 25/01/18
Internet address	https://www.mems2018.org/

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/MEMSYS.2018.8346541

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Sinha, A., Tai, T.-Y., Wang, Y.-L., & Lee, G.-B. (2018). INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS. In 2018 IEEE Micro Electro Mechanical Systems (MEMS) (pp. 286-289). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). IEEE. https://doi.org/10.1109/MEMSYS.2018.8346541

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title = "INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS",

abstract = "This study presents an integrated microfluidic platform equipped with a field-effect-transistor sensor array which is capable of performing analysis beyond Debye length and detecting protein biomarkers associated with cardiovascular diseases from clinical samples within a short period of time. This work also demonstrates a prototype for future point-of-care device on which antibodies could be replaced by highly specific aptamers. In order to demonstrate the capability of the developed device, four cardiovascular biomarkers (CRP, NT-proBNP, troponin I, fibrinogen) were chosen and their physiological as well as risk concentrations were analyzed simultaneously in a single chip.",

author = "Anirban Sinha and Tse-Yu Tai and Yu-Lin Wang and Gwo-Bin Lee",

year = "2018",

month = jan,

doi = "10.1109/MEMSYS.2018.8346541",

language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "IEEE",

pages = "286--289",

booktitle = "2018 IEEE Micro Electro Mechanical Systems (MEMS)",

address = "United States",

note = "31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018) ; Conference date: 21-01-2018 Through 25-01-2018",

url = "https://www.mems2018.org/",

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Sinha, A, Tai, T-Y, Wang, Y-L & Lee, G-B 2018, INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS. in 2018 IEEE Micro Electro Mechanical Systems (MEMS). Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), IEEE, pp. 286-289, 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2018), Belfast, United Kingdom, 21/01/18. https://doi.org/10.1109/MEMSYS.2018.8346541

INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS. / Sinha, Anirban; Tai, Tse-Yu; Wang, Yu-Lin et al.
2018 IEEE Micro Electro Mechanical Systems (MEMS). IEEE, 2018. p. 286-289 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

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AB - This study presents an integrated microfluidic platform equipped with a field-effect-transistor sensor array which is capable of performing analysis beyond Debye length and detecting protein biomarkers associated with cardiovascular diseases from clinical samples within a short period of time. This work also demonstrates a prototype for future point-of-care device on which antibodies could be replaced by highly specific aptamers. In order to demonstrate the capability of the developed device, four cardiovascular biomarkers (CRP, NT-proBNP, troponin I, fibrinogen) were chosen and their physiological as well as risk concentrations were analyzed simultaneously in a single chip.

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INTEGRATED MICROFLUIDIC SYSTEM WITH FIELD EFFECT TRANSISTOR FOR AUTOMATIC DETECTION OF MULTIPLE CARDIOVASCULAR BIOMARKERS

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