Integrated Microfluidic Synthesis of Aptamer Functionalized Biozeolitic Imidazolate Framework (BioZIF-8) Targeting Lymph Node and Tumor

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

34 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)1335-1344
Journal / PublicationNano Letters
Volume21
Issue number3
Online published1 Feb 2021
Publication statusPublished - 10 Feb 2021
Externally publishedYes

Abstract

Targeted delivery of therapeutic molecules using nanomaterials is desired to elicit specific responses toward diseases. Such an integrated synthesis of functional material using a microfluidic approach is a great challenge. Functional metal organic frameworks (MOFs) with unique structural diversity possess a complicated synthesis procedure thereby requiring a modest, straightforward approach to synthesize size-controllable MOFs. Here, we develop an integrated microfluidic chip to synthesize the aptamer-modified biozeolitic imidazolate framework (BioZIF-8) to target the lymph node and tumor. The first stage of the microfluidic chip forms the ZIF-8 encapsulating biomolecules (bovine serum albumin, small interfering ribonucleic acid, and doxorubicin). The second stage modifies the surface of BioZIF-8 with the aptamer. Our approach reduces the overall synthesis time (∼3 mg/10 min against 15 h for the conventional two-step method) and encapsulates a higher number of biomolecules. The microfluidic approach realizes the rapid and fine-tuned synthesis of functional MOFs integrated into one-step. © 2021 American Chemical Society.

Research Area(s)

  • BioZIF-8 MOFs, drug delivery, lymph nodes, Microfluidics, tumor

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