Integrated metabolomics revealed the photothermal therapy of melanoma by Mo2C nanosheets : toward rehabilitated homeostasis in metabolome combined lipidome

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

View graph of relations

Author(s)

  • Dingkun Zhang
  • Ming Wang
  • Yijin Li
  • Ge Liang
  • Wen Zheng
  • Luolan Gui
  • Xin Li
  • Lu Zhang
  • Wenjuan Zeng
  • Yin Yang
  • Yu Zeng
  • Zhe Huang
  • Junwen Guan
  • Tao Li
  • Jingqiu Cheng
  • Hao Yang
  • Ligang Chen
  • Jie Zhou
  • Meng Gong

Detail(s)

Original languageEnglish
Pages (from-to)730-741
Journal / PublicationJournal of Materials Chemistry B
Volume12
Issue number3
Online published4 Dec 2023
Publication statusPublished - 21 Jan 2024

Abstract

Melanoma, the most aggressive and life-threatening form of skin cancer, lacks innovative therapeutic approaches and deeper bioinformation. In this study, we developed a photothermal therapy (PTT) based on Mo2C nanosheets to eliminate melanoma while utilizing integrated metabolomics to investigate the metabolic shift of metabolome combined lipidome during PTT at the molecular level. Our results demonstrated that 1 mg ml−1 Mo2C nanosheets could efficiently convert laser energy into heat with a strong and stable photothermal effect (74 ± 0.9 °C within 7 cycles). Furthermore, Mo2C-based PTT led to a rapid decrease in melanoma volume (from 3.299 to 0 cm2) on the sixth day, indicating the effective elimination of melanoma. Subsequent integrated metabolomics analysis revealed significant changes in aqueous metabolites (including organic acids, amino acids, fatty acids, and amines) and lipid classes (including phospholipids, lysophospholipids, and sphingolipids), suggesting that melanoma caused substantial fluctuations in both metabolome and lipidome, while Mo2C-based PTT helped improve amino acid metabolism-related biological events (such as tryptophan metabolism) impaired by melanoma. These findings suggest that Mo2C nanosheets hold significant potential as an effective therapeutic agent for skin tumors, such as melanoma. Moreover, through exploring multidimensional bioinformation, integrated metabolomics technology provides novel insights for studying the metabolic effects of tumors, monitoring the correction of metabolic abnormalities by Mo2C nanosheet therapy, and evaluating the therapeutic effect on tumors. © 2024 The Royal Society of Chemistry.

Citation Format(s)

Integrated metabolomics revealed the photothermal therapy of melanoma by Mo2C nanosheets: toward rehabilitated homeostasis in metabolome combined lipidome. / Zhang, Dingkun; Wang, Ming; Li, Yijin et al.
In: Journal of Materials Chemistry B, Vol. 12, No. 3, 21.01.2024, p. 730-741.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review