Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging

Chien-Liang Liu; Hung-Tsung Wu; Yi-Hsuan Hsiao; Chih-Wei Lai; Chun-Wei Shih; Yung-Kang Peng; Kuo-Chun Tang; Hsing-Wei Chang; Yun-Chen Chien; Jong-Kai Hsiao; Juei-Tang Cheng; Pi-Tai Chou

doi:10.1002/anie.201100299

Author(s)

Chien-Liang Liu
Hung-Tsung Wu
Yi-Hsuan Hsiao
Chih-Wei Lai
Chun-Wei Shih
Kuo-Chun Tang
Hsing-Wei Chang
Yun-Chen Chien
Jong-Kai Hsiao
Juei-Tang Cheng
Pi-Tai Chou

Detail(s)

Original language	English
Pages (from-to)	7056-7060
Journal / Publication	Angewandte Chemie - International Edition
Volume	50
Issue number	31
Online published	17 Jun 2011
Publication status	Published - 25 Jul 2011
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1002/anie.201100299 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-79960645506&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(691291a2-2098-4088-bc12-875f37a6aea3).html

Abstract

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

Research Area(s)

biomaterials, fluorescence, gold, imaging agents, nanostructures

Citation Format(s)

[ RIS ] [ BibTeX ]

Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters : Preservation of Insulin Bioactivity and Versatility in Cell Imaging. / Liu, Chien-Liang; Wu, Hung-Tsung; Hsiao, Yi-Hsuan et al.

In: Angewandte Chemie - International Edition, Vol. 50, No. 31, 25.07.2011, p. 7056-7060.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Liu, C-L, Wu, H-T, Hsiao, Y-H, Lai, C-W, Shih, C-W, Peng, Y-K, Tang, K-C, Chang, H-W, Chien, Y-C, Hsiao, J-K, Cheng, J-T & Chou, P-T 2011, 'Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging', Angewandte Chemie - International Edition, vol. 50, no. 31, pp. 7056-7060. https://doi.org/10.1002/anie.201100299

Liu, C-L., Wu, H-T., Hsiao, Y-H., Lai, C-W., Shih, C-W., Peng, Y-K., Tang, K-C., Chang, H-W., Chien, Y-C., Hsiao, J-K., Cheng, J-T., & Chou, P-T. (2011). Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging. Angewandte Chemie - International Edition, 50(31), 7056-7060. https://doi.org/10.1002/anie.201100299

Liu C-L, Wu H-T, Hsiao Y-H, Lai C-W, Shih C-W, Peng Y-K et al. Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging. Angewandte Chemie - International Edition. 2011 Jul 25;50(31):7056-7060. Epub 2011 Jun 17. doi: 10.1002/anie.201100299

Liu, Chien-Liang ; Wu, Hung-Tsung ; Hsiao, Yi-Hsuan et al. / Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters : Preservation of Insulin Bioactivity and Versatility in Cell Imaging. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 31. pp. 7056-7060.