Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging

Chien-Liang Liu; Hung-Tsung Wu; Yi-Hsuan Hsiao; Chih-Wei Lai; Chun-Wei Shih; Yung-Kang Peng; Kuo-Chun Tang; Hsing-Wei Chang; Yun-Chen Chien; Jong-Kai Hsiao; Juei-Tang Cheng; Pi-Tai Chou

doi:10.1002/anie.201100299

Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging

Chien-Liang Liu, Hung-Tsung Wu, Yi-Hsuan Hsiao, Chih-Wei Lai, Chun-Wei Shih, Yung-Kang Peng, Kuo-Chun Tang, Hsing-Wei Chang, Yun-Chen Chien, Jong-Kai Hsiao, Juei-Tang Cheng, Pi-Tai Chou

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

406 Citations (Scopus)

Abstract

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

Original language	English
Pages (from-to)	7056-7060
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	31
Online published	17 Jun 2011
DOIs	https://doi.org/10.1002/anie.201100299
Publication status	Published - 25 Jul 2011
Externally published	Yes

Research Keywords

biomaterials
fluorescence
gold
imaging agents
nanostructures

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10.1002/anie.201100299

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Liu, C.-L., Wu, H.-T., Hsiao, Y.-H., Lai, C.-W., Shih, C.-W., Peng, Y.-K., Tang, K.-C., Chang, H.-W., Chien, Y.-C., Hsiao, J.-K., Cheng, J.-T., & Chou, P.-T. (2011). Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging. Angewandte Chemie - International Edition, 50(31), 7056-7060. https://doi.org/10.1002/anie.201100299

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abstract = "Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).",

keywords = "biomaterials, fluorescence, gold, imaging agents, nanostructures",

author = "Chien-Liang Liu and Hung-Tsung Wu and Yi-Hsuan Hsiao and Chih-Wei Lai and Chun-Wei Shih and Yung-Kang Peng and Kuo-Chun Tang and Hsing-Wei Chang and Yun-Chen Chien and Jong-Kai Hsiao and Juei-Tang Cheng and Pi-Tai Chou",

year = "2011",

month = jul,

day = "25",

doi = "10.1002/anie.201100299",

language = "English",

volume = "50",

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journal = "Angewandte Chemie - International Edition",

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Liu, C-L, Wu, H-T, Hsiao, Y-H, Lai, C-W, Shih, C-W, Peng, Y-K, Tang, K-C, Chang, H-W, Chien, Y-C, Hsiao, J-K, Cheng, J-T & Chou, P-T 2011, 'Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging', Angewandte Chemie - International Edition, vol. 50, no. 31, pp. 7056-7060. https://doi.org/10.1002/anie.201100299

Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging. / Liu, Chien-Liang; Wu, Hung-Tsung; Hsiao, Yi-Hsuan et al.
In: Angewandte Chemie - International Edition, Vol. 50, No. 31, 25.07.2011, p. 7056-7060.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters

T2 - Preservation of Insulin Bioactivity and Versatility in Cell Imaging

AU - Liu, Chien-Liang

AU - Wu, Hung-Tsung

AU - Hsiao, Yi-Hsuan

AU - Lai, Chih-Wei

AU - Shih, Chun-Wei

AU - Peng, Yung-Kang

AU - Tang, Kuo-Chun

AU - Chang, Hsing-Wei

AU - Chien, Yun-Chen

AU - Hsiao, Jong-Kai

AU - Cheng, Juei-Tang

AU - Chou, Pi-Tai

PY - 2011/7/25

Y1 - 2011/7/25

N2 - Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

AB - Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

KW - biomaterials

KW - fluorescence

KW - gold

KW - imaging agents

KW - nanostructures

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-79960645506&origin=recordpage

U2 - 10.1002/anie.201100299

DO - 10.1002/anie.201100299

M3 - RGC 21 - Publication in refereed journal

C2 - 21688357

SN - 1433-7851

VL - 50

SP - 7056

EP - 7060

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 31

ER -

Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging

Abstract

Research Keywords

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