Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xueying Kang
  • Haishun Ye
  • Shanshan Liu
  • Xiaoqiang Tu
  • Jiqin Zhu
  • Long Yi

Detail(s)

Original languageEnglish
Pages (from-to)4233-4236
Journal / PublicationChemical Communications
Volume59
Issue number28
Online published14 Mar 2023
Publication statusPublished - 11 Apr 2023

Abstract

An unprecedented H2S release from cysteine esters and amides (CysO/NHR) under physiological conditions was discovered and the plausible mechanism was proposed. Alkylation of the amino moiety of cysteine esters enables the H2S release to be tuned and further provides support to the mechanistic insights. This discovery not only provides new insights into several fundamental science issues including non-enzymatic H2S-produced pathways, but also inspires new tunable cleavable motifs for sustained release of arylthiols and even for prodrug design.

Research Area(s)

  • HYDROGEN-SULFIDE, SMALL-MOLECULE, H2S DONORS, AMINO-ACIDS, IDENTIFICATION, DERIVATIVES, MODULATION, DELIVERY, CANCER, PROBES

Citation Format(s)

Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry. / Kang, Xueying; Ye, Haishun; Liu, Shanshan et al.
In: Chemical Communications, Vol. 59, No. 28, 11.04.2023, p. 4233-4236.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review