InSe Nanosheets for Efficient NIR-II-Responsive Drug Release

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

1 Scopus Citations
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Author(s)

  • Chi Huang
  • Zhengbo Sun
  • Haodong Cui
  • Ting Pan
  • Shengyong Geng
  • Wenhua Zhou
  • Xue-Feng Yu

Detail(s)

Original languageEnglish
Pages (from-to)27521−27528
Journal / PublicationACS Applied Materials and Interfaces
Volume11
Issue number31
Online published10 Jun 2019
Publication statusPublished - 7 Aug 2019

Abstract

Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.

Research Area(s)

  • cancer treatment, drug release, InSe, NIR-II, two-dimensional nanomaterials

Citation Format(s)

InSe Nanosheets for Efficient NIR-II-Responsive Drug Release. / Huang, Chi; Sun, Zhengbo; Cui, Haodong; Pan, Ting; Geng, Shengyong; Zhou, Wenhua; Chu, Paul K.; Yu, Xue-Feng.

In: ACS Applied Materials and Interfaces, Vol. 11, No. 31, 07.08.2019, p. 27521−27528.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review