InSe Nanosheets for Efficient NIR-II-Responsive Drug Release

Chi Huang; Zhengbo Sun; Haodong Cui; Ting Pan; Shengyong Geng; Wenhua Zhou; Paul K. Chu; Xue-Feng Yu

doi:10.1021/acsami.9b06170

InSe Nanosheets for Efficient NIR-II-Responsive Drug Release

Chi Huang
, Zhengbo Sun
, Haodong Cui
, Ting Pan
, Shengyong Geng
, Wenhua Zhou^*
, Paul K. Chu
, Xue-Feng Yu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

36 Citations (Scopus)

Abstract

Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.

Original language	English
Pages (from-to)	27521−27528
Journal	ACS Applied Materials and Interfaces
Volume	11
Issue number	31
Online published	10 Jun 2019
DOIs	https://doi.org/10.1021/acsami.9b06170
Publication status	Published - 7 Aug 2019

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

cancer treatment
drug release
InSe
NIR-II
two-dimensional nanomaterials

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10.1021/acsami.9b06170

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@article{fe19b952a09346a5bf9f307ca8186057,

title = "InSe Nanosheets for Efficient NIR-II-Responsive Drug Release",

abstract = "Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5\%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6\%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.",

keywords = "cancer treatment, drug release, InSe, NIR-II, two-dimensional nanomaterials",

author = "Chi Huang and Zhengbo Sun and Haodong Cui and Ting Pan and Shengyong Geng and Wenhua Zhou and Chu, \{Paul K.\} and Xue-Feng Yu",

year = "2019",

month = aug,

day = "7",

doi = "10.1021/acsami.9b06170",

language = "English",

volume = "11",

pages = "27521−27528",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "31",

}

TY - JOUR

T1 - InSe Nanosheets for Efficient NIR-II-Responsive Drug Release

AU - Huang, Chi

AU - Sun, Zhengbo

AU - Cui, Haodong

AU - Pan, Ting

AU - Geng, Shengyong

AU - Zhou, Wenhua

AU - Chu, Paul K.

AU - Yu, Xue-Feng

PY - 2019/8/7

Y1 - 2019/8/7

N2 - Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.

AB - Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.

KW - cancer treatment

KW - drug release

KW - InSe

KW - NIR-II

KW - two-dimensional nanomaterials

UR - https://www.scopus.com/pages/publications/85068186255

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85068186255&origin=recordpage

U2 - 10.1021/acsami.9b06170

DO - 10.1021/acsami.9b06170

M3 - RGC 21 - Publication in refereed journal

SN - 1944-8244

VL - 11

SP - 27521−27528

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 31

ER -

InSe Nanosheets for Efficient NIR-II-Responsive Drug Release

Abstract

UN SDGs

Research Keywords

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