Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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Author(s)

  • Songshan Li
  • Qinghai He
  • Hao Wang
  • Xuming Tang
  • Kam Wing Ho
  • Xin Gao
  • Qian Zhang
  • Yang Shen
  • Annie Cheung
  • Francis Wong
  • Yung Hou Wong
  • Nancy Y. Ip
  • Liwen Jiang
  • Kai Liu

Detail(s)

Original languageEnglish
Pages (from-to)366-376
Journal / PublicationNeurobiology of Disease
Volume73
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-84909960038&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(1291b900-cb7d-4560-8cbe-d4676842097b).html

Abstract

Despite advances in promoting axonal regeneration after adult central nervous system injury, elicitation of a large number of lesion-passing axons reform active synaptic connections with natural target neurons remains limited. By deleting both Pten and Socs3 in retinal ganglion cells, we report that optic nerve axons after prechiasm lesion robustly reinnervate the hypothalamus, form new synapses with neurons in the suprachiasmatic nucleus (SCN), and re-integrate with the existing circuitry. Photic or electric stimulation of the retinal axons induces neuronal response in SCN. However both the innervation pattern and evoked responses are not completely restored by the regenerating axons, suggesting that combining with other strategies is necessary to overcome the defective rewiring. Our results support that boosting the intrinsic growth capacity in injured neurons promotes axonal reinnervation and rewiring. © 2014 Published by Elsevier Inc.

Research Area(s)

  • Axon regeneration and rewiring, Intrinsic mechanisms, Pre-chiasm lesion, Retinal ganglion cells, Suprachiasmatic nucleus

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

[ RIS ] [ BibTeX ]
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. / Li, Songshan; He, Qinghai; Wang, Hao et al.
In: Neurobiology of Disease, Vol. 73, 01.01.2015, p. 366-376.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review