Abstract
Heme-nonapeptide, derived from cytochrome c, inhibited both the NADPH- and NADH-dependent lipid peroxidation of brain microsomes but, in the case of liver microsomes, this inhibitory effect manifested itself in the presence of SKF-525A (a specific Mocker of cytochrome P-450) only. Heme-nonapeptide prevented the transient accumulation of lipid peroxides in microsomes during lipid peroxidation. The oxygen consumption of microsomes in the presence of NADPH or NADH was stimulated by heme-nonapeptide. From these results we concluded that, in vitro, there are two independent mechanisms of lipid peroxidation in liver microsomes. It is suggested that, in vivo, the heme-peptide-sensitive mechanism, observed in brain microsomes, is more important. © 1985.
| Original language | English |
|---|---|
| Pages (from-to) | 411-414 |
| Journal | Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism |
| Volume | 835 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 9 Jul 1985 |
| Externally published | Yes |
Research Keywords
- (Brain and liver microsome)
- Heme-nonapeptide inhibitor
- Lipid peroxidation
- SKF-525A
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