Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiang-Ping Li
  • Christine Y.S. Li
  • Xiaohua Li
  • Yanqing Ding
  • Lally L.Y. Chan
  • Pai-Hao Yang
  • Gang Li
  • Xiong Liu
  • Jennifer S. Lin
  • Jide Wang
  • Hsiang-Fu Kung
  • Marie C. Lin
  • Ying Peng

Detail(s)

Original languageEnglish
Pages (from-to)1290-1299
Journal / PublicationMolecular Cancer Therapeutics
Volume5
Issue number5
Publication statusPublished - May 2006
Externally publishedYes

Abstract

Nasopharyngeal carcinoma (NPC) is a highly malignant and frequently metastasized tumor. Endostatin has been shown to inhibit NPC growth, but its efficacy against NPC metastasis has not been shown in vivo. Here, we established a NPC metastasis model in mice by transplanting EBV-positive NPC cells, C666-1, in the livers of nude mice and observed lung metastasis. Furthermore, we showed that tall vein injection of recombinant adeno-associated virus encoding human endostatin (rAAV-hEndo) significantly prolonged the median survival rate of NPC metastasis-bearing mice (from 22 to 37 days, P <0.01). The rAAV-hEndo treatment resulted in a statistically significant reduction in tumor growth and microvessel formation. It also increased the apoptotic index in the primary liver tumor but not in the normal liver tissue. Importantly, no formation of liver or lung metastasis was detected. The potent inhibition of NPC metastasis suggests the feasibility of combining rAAV-hEndo gene therapy with other therapies for the prevention and treatment of NPC metastasis. Copyright © 2006 American Association for Cancer Research.

Citation Format(s)

Inhibition of human nasopharyngeal carcinoma growth and metastasis in mice by adenovirus-associated virus-mediated expression of human endostatin. / Li, Xiang-Ping; Li, Christine Y.S.; Li, Xiaohua; Ding, Yanqing; Chan, Lally L.Y.; Yang, Pai-Hao; Li, Gang; Liu, Xiong; Lin, Jennifer S.; Wang, Jide; He, Mingliang; Kung, Hsiang-Fu; Lin, Marie C.; Peng, Ying.

In: Molecular Cancer Therapeutics, Vol. 5, No. 5, 05.2006, p. 1290-1299.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review