Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities

Changqing Yi; Chi-Chun Fong; Weiwei Chen; Suijian Qi; Shuit-Tong Lee; Mengsu Yang

doi:10.1002/cbic.200700136

Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities

Changqing Yi, Chi-Chun Fong, Weiwei Chen, Suijian Qi, Shuit-Tong Lee, Mengsu Yang

Centre of Super-Diamond and Advanced Films

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

10 Citations (Scopus)

Abstract

(Figure Presented) Through the wire. We have investigated the potential effects of silicon nanowires (SiNW-SiO₂) and SiNWs functionalized with carboxylic groups (SiNW-COOH) on restriction endonucleases and Taq DNA polymerase. The results show that these SiNWs can inhibit enzyme activity (lower band in gel). Our findings suggest that this could be due to chemical interactions between the functional groups on SiNWs and the enzymes. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	1225-1229
Journal	ChemBioChem
Volume	8
Issue number	11
DOIs	https://doi.org/10.1002/cbic.200700136
Publication status	Published - 23 Jul 2007

Research Keywords

DNA
Enzymes
Nanostructures
Polymerase chain reaction

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title = "Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities",

abstract = "(Figure Presented) Through the wire. We have investigated the potential effects of silicon nanowires (SiNW-SiO2) and SiNWs functionalized with carboxylic groups (SiNW-COOH) on restriction endonucleases and Taq DNA polymerase. The results show that these SiNWs can inhibit enzyme activity (lower band in gel). Our findings suggest that this could be due to chemical interactions between the functional groups on SiNWs and the enzymes. {\textcopyright} 2007 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "DNA, Enzymes, Nanostructures, Polymerase chain reaction",

author = "Changqing Yi and Chi-Chun Fong and Weiwei Chen and Suijian Qi and Shuit-Tong Lee and Mengsu Yang",

year = "2007",

month = jul,

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doi = "10.1002/cbic.200700136",

language = "English",

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TY - JOUR

T1 - Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities

AU - Yi, Changqing

AU - Fong, Chi-Chun

AU - Chen, Weiwei

AU - Qi, Suijian

AU - Lee, Shuit-Tong

AU - Yang, Mengsu

PY - 2007/7/23

Y1 - 2007/7/23

N2 - (Figure Presented) Through the wire. We have investigated the potential effects of silicon nanowires (SiNW-SiO2) and SiNWs functionalized with carboxylic groups (SiNW-COOH) on restriction endonucleases and Taq DNA polymerase. The results show that these SiNWs can inhibit enzyme activity (lower band in gel). Our findings suggest that this could be due to chemical interactions between the functional groups on SiNWs and the enzymes. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - (Figure Presented) Through the wire. We have investigated the potential effects of silicon nanowires (SiNW-SiO2) and SiNWs functionalized with carboxylic groups (SiNW-COOH) on restriction endonucleases and Taq DNA polymerase. The results show that these SiNWs can inhibit enzyme activity (lower band in gel). Our findings suggest that this could be due to chemical interactions between the functional groups on SiNWs and the enzymes. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - DNA

KW - Enzymes

KW - Nanostructures

KW - Polymerase chain reaction

UR - http://www.scopus.com/inward/record.url?scp=34547427470&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-34547427470&origin=recordpage

U2 - 10.1002/cbic.200700136

DO - 10.1002/cbic.200700136

M3 - RGC 21 - Publication in refereed journal

C2 - 17566125

SN - 1439-4227

VL - 8

SP - 1225

EP - 1229

JO - ChemBioChem

JF - ChemBioChem

IS - 11

ER -

Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities

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Research Keywords

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